| | |  | | | | Record from Web of Science® | | | | | | |
| A SIMPLE GENETIC-BASIS FOR A COMPLEX PSYCHOLOGICAL TRAIT IN LABORATORY MICE |
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| Author(s): FLINT J, CORLEY R, DEFRIES JC, FULKER DW, GRAY JA, MILLER S, COLLINS AC |
| Source: SCIENCE Volume: 269 Issue: 5229 Pages: 1432-1435 Published: SEP 8 1995 |
| Times Cited: 267 References: 41 |
| Abstract: Psychological traits are commonly inferred from covariation in sets of behavioral measures that otherwise appear to have little in common. Emotionality in mice is such a trait, defined here by covariation in activity and defecation in a novel environment and emergence into the open arms of an elevated plus maze. Behavioral and quantitative trait analyses were conducted on four measures obtained from 879 mice from an F-2 intercross. Three loci, on murine chromosomes 1, 12, and 15, were mapped that influence emotionality. This trait, inferred from studies of strain, sex, and individual differences in rodents, may be related to human susceptibility to anxiety or neuroticism. |
| Document Type: Article |
| Language: English |
| Reprint Address: FLINT, J (reprint author), JOHN RADCLIFFE HOSP, INST MOLEC MED, OXFORD OX3 9DU, ENGLAND |
Addresses:
1. UNIV COLORADO, INST BEHAV GENET, BOULDER, CO 80309 USA
2. INST PSYCHIAT, LONDON SE5 8AF, ENGLAND |
| Publisher: AMER ASSOC ADVAN SCIENCE, 1333 H ST NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: RT806 |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |