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| DECREASED MUSCARINIC RECEPTOR-BINDING IN THE ARCUATE NUCLEUS IN SUDDEN-INFANT-DEATH-SYNDROME |
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| Author(s): KINNEY HC, FILIANO JJ, SLEEPER LA, MANDELL F, VALDESDAPENA M, WHITE WF |
| Source: SCIENCE Volume: 269 Issue: 5229 Pages: 1446-1450 Published: SEP 8 1995 |
| Times Cited: 180 References: 42 |
| Abstract: Muscarinic cholinergic activity in the human arcuate nucleus at the ventral medullary surface is postulated to be involved in cardiopulmonary control, A significant decrease in [H-3]quinuclidinyl benzilate binding to muscarinic receptors in the arcuate nucleus is now shown to occur in sudden infant death syndrome (SIDS) infants, compared to infants dying acutely of known causes. In infants with chronic oxygenation abnormalities, binding is low in other nuclei, as well as in the arcuate nucleus. The binding deficit in the arcuate nucleus of SIDS infants might contribute to a failure of responses to cardiopulmonary challenges during sleep. |
| Document Type: Article |
| Language: English |
| Reprint Address: KINNEY, HC (reprint author), CHILDRENS HOSP, DEPT PATHOL, BOSTON, MA 02115 USA |
Addresses:
1. CHILDRENS HOSP, DEPT NEUROL, BOSTON, MA 02115 USA
2. HARVARD UNIV, SCH MED, BOSTON, MA 02115 USA
3. NEW ENGLAND RES INST, WATERTOWN, MA 02172 USA
4. CHILDRENS HOSP, DEPT PEDIAT, BOSTON, MA 02115 USA
5. UNIV MIAMI, SCH MED, DEPT PATHOL, MIAMI, FL 33101 USA
6. PFIZER INC, CENT RES, DEPT NEUROSCI, GROTON, CT 06340 USA |
| Publisher: AMER ASSOC ADVAN SCIENCE, 1333 H ST NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: RT806 |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |