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| TEL1, AN SACCHAROMYCES-CEREVISIAE HOMOLOG OF THE HUMAN GENE MUTATED IN ATAXIA-TELANGIECTASIA, IS FUNCTIONALLY RELATED TO THE YEAST CHECKPOINT GENE MEC1 |
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| Author(s): MORROW DM, MORROW M, TAGLE DA, SHILOH Y, COLLINS FS, HIETER P |
| Source: CELL Volume: 82 Issue: 5 Pages: 831-840 Published: SEP 8 1995 |
| Times Cited: 275 References: 48 |
| Abstract: Patients with the genetic disorder ataxia telangiectasia (AT) have mutations in the AT mutated (ATM) gene, which is homologous to TEL1 and the checkpoint gene MEC1. A tel1 deletion mutant, unlike a mec1 deletion, is viable and does not exhibit increased sensitivity to DNA-damaging agents. However, increased dosage of TEL1 rescues sensitivity of a mec1 mutant, mec1-1, to DNA-damaging agents and rescues viability of a mec1 disruption. mec1-1 tel1 Delta 1 double mutants are synergistically sensitive to DNA-damaging agents, including radiomimetic drugs. These data indicate that TEL1 and MEC1 are functionally related and that functions of the ATM gene are apparently divided between at least two S. cerevisiae homologs. |
| Document Type: Article |
| Language: English |
| Reprint Address: MORROW, DM (reprint author), JOHNS HOPKINS UNIV, SCH MED, DEPT MOLEC BIOL & GENET, BALTIMORE, MD 21205 USA |
Addresses:
1. NIH, NATL CTR HUMAN GENOME RES, GENE TRANSFER LAB, BETHESDA, MD 20892 USA
2. TEL AVIV UNIV, SACKLER SCH MED, DEPT HUMAN GENET, IL-69978 TEL AVIV, ISRAEL |
| Publisher: CELL PRESS, 50 CHURCH ST CIRCULATION DEPT, CAMBRIDGE, MA 02138 |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology |
| IDS Number: RU755 |
| ISSN: 0092-8674 |
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