| | |  | | | | Record from Web of Science® | | | | | | |
| ANTIBODY ENGINEERING |
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| Author(s): NILSSON B |
| Source: CURRENT OPINION IN STRUCTURAL BIOLOGY Volume: 5 Issue: 4 Pages: 450-456 Published: AUG 1995 |
| Times Cited: 15 References: 77 |
| Abstract: Antibody engineering has been an extremely intensive research area for many years. Recent achievements discussed in this review include: (i) significant improvements in the field of selection of antigen-specific antibody fragments on bacteriophages; (ii) new structural work, in particular using NMR; (iii) the cloning of essentially the complete set of human V-H genes; (iv) the use of antibodies to catalyze complicated chemical reactions; and (v) novel antibody fusion proteins to potentiate immune therapy. An interesting new development is the replacement of antibodies with more stable protein scaffolds for many future biotechnological applications. |
| Document Type: Article |
| Language: English |
| Reprint Address: NILSSON, B (reprint author), PHARMACIA AB, DEPT BIOL STRUCT, BIOPHARMACEUT, MAILCODE N62-6, S-11287 STOCKHOLM, SWEDEN |
| Publisher: CURRENT BIOLOGY LTD, 34-42 CLEVELAND STREET, LONDON, ENGLAND W1P 6LB |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology |
| IDS Number: RV272 |
| ISSN: 0959-440X |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |