| | |  | | | | Record from Web of Science® | | | | | | |
| BENIGN AND MALIGNANT BREAST-LESIONS - DIFFERENTIATION WITH ECHO-PLANAR MR-IMAGING |
|
|
| Author(s): HULKA CA, SMITH BL, SGROI DC, TAN LJ, EDMISTER WB, SEMPLE JP, CAMPBELL T, KOPANS DB, BRADY TJ, WEISSKOFF RM |
| Source: RADIOLOGY Volume: 197 Issue: 1 Pages: 33-38 Published: OCT 1995 |
| Times Cited: 146 References: 28 |
| Abstract: PURPOSE: To quantify dynamic enhancement of breast lesions with echo-planar and conventional magnetic resonance (MR) imaging, to correlate these data with histologic findings and vessel density, and to evaluate the effect of T1 values on enhancement data. MATERIALS AND METHODS: Twenty female patients with 22 breast lesions underwent conventional and echo-planar MR imaging. T1 values, change in gadopentetate dimeglumine concentration, and extraction-flow products were calculated with echo-planar imaging data and were correlated with histologic findings and microvessel density.
RESULTS: T1 values of cancers were not statistically significantly shorter. Cancers had more rapid uptake and higher extraction-flow products (P < .02). Sensitivity was 86% and specificity was 93% for diagnosis of malignancy. Microvessel density was higher far malignant lesions (P < .02) with an overall positive (not statistically significant) correlation between extraction-flow product and microvessel density.
CONCLUSION Echo-planar imaging appears promising for quantification of breast lesion enhancement. Microvessel data indicate that tumor angiogenesis affects enhancement.
|
| Document Type: Proceedings Paper |
| Language: English |
| Reprint Address: HULKA, CA (reprint author), MASSACHUSETTS GEN HOSP, DEPT RADIOL, FRUIT ST, BOSTON, MA 02114 USA |
Addresses:
1. MASSACHUSETTS GEN HOSP, CTR NUCL MAGNET RESONANCE, BOSTON, MA 02114 USA
2. MASSACHUSETTS GEN HOSP, DEPT SURG, BOSTON, MA 02114 USA
3. MASSACHUSETTS GEN HOSP, DEPT PATHOL, BOSTON, MA 02114 USA
4. HARVARD UNIV, SCH MED, BOSTON, MA 02114 USA
5. TUFTS UNIV, NEW ENGLAND MED CTR, SCH MED, DEPT PATHOL, BOSTON, MA 02111 USA |
| Publisher: RADIOLOGICAL SOC NORTH AMER, 20TH AND NORTHAMPTON STS, EASTON, PA 18042 |
| Subject Category: Radiology, Nuclear Medicine & Medical Imaging |
| IDS Number: RV899 |
| ISSN: 0033-8419 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |