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| RECEPTOR TYROSINE KINASE SPECIFIC FOR THE SKELETAL-MUSCLE LINEAGE - EXPRESSION IN EMBRYONIC MUSCLE, AT THE NEUROMUSCULAR-JUNCTION, AND AFTER INJURY |
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| Author(s): VALENZUELA DM, STITT TN, DISTEFANO PS, ROJAS E, MATTSSON K, COMPTON DL, NUNEZ L, PARK JS, STARK JL, GIES DR, THOMAS S, LEBEAU MM, FERNALD AA, COPELAND NG, JENKINS NA, BURDEN SJ, GLASS DJ, YANCOPOULOS GD |
| Source: NEURON Volume: 15 Issue: 3 Pages: 573-584 Published: SEP 1995 |
| Times Cited: 242 References: 41 |
| Abstract: While a number of growth factors have been described that are highly specific for particular cell lineages, neither a factor nor a receptor uniquely specific to the skeletal muscle lineage has previously been described. Here we identify a receptor tyrosine kinase (RTK) specific to skeletal muscle, which we term ''MuSK'' for muscle-specific kinase. MuSK is expressed at low levels in proliferating myoblasts and is induced upon differentiation and fusion, In the embryo, it is specifically expressed in early myotomes and developing muscle. MUSK is then dramatically down-regulated in mature muscle, where it remains prominent only at the neuromuscular junction; MuSK is thus the only known RTK that localizes to the neuromuscular junction. Strikingly, MuSK expression is dramatically induced throughout the adult myofiber after denervation, block of electrical activity, or physical immobilization. In humans, MuSK maps to chromosome 9q31.3-32, which overlaps with the region reported to contain the Fukuyama muscular dystrophy mutation. Identification of MUSK introduces a novel receptor-factor system that seems sure to play an important and selective role in many aspects of skeletal muscle development and function. |
| Document Type: Article |
| Language: English |
| Reprint Address: VALENZUELA, DM (reprint author), REGENERON PHARMACEUT INC, 777 OLD SAW MILL RIVER RD, TARRYTOWN, NY 10591 USA |
Addresses:
1. NYU, MED CTR, SKIRBALL INST, NEW YORK, NY 10016 USA
2. UNIV CHICAGO, DEPT MED, HEMATOL ONCOL SECT, CHICAGO, IL 60637 USA
3. NATL CANC INST, FREDERICK CANC RES CTR, ABL BASIC RES PROGRAM, MAMMALIAN GENET LAB, FREDERICK, MD 21703 USA |
| Publisher: CELL PRESS, 50 CHURCH ST CIRCULATION DEPT, CAMBRIDGE, MA 02138 |
| Subject Category: Neurosciences |
| IDS Number: RV945 |
| ISSN: 0896-6273 |
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