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| DETECTION OF KAPOSI-SARCOMA ASSOCIATED HERPESVIRUS IN PERIPHERAL-BLOOD OF HIV-INFECTED INDIVIDUALS AND PROGRESSION TO KAPOSIS-SARCOMA |
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| Author(s): WHITBY D, HOWARD MR, TENANTFLOWERS M, BRINK NS, COPAS A, BOSHOFF C, HATZIOANNOU T, SUGGETT FEA, ALDAM DM, DENTON AS, MILLER RF, WELLER IVD, WEISS RA, TEDDER RS, SCHULZ TF |
| Source: LANCET Volume: 346 Issue: 8978 Pages: 799-802 Published: SEP 23 1995 |
| Times Cited: 629 References: 28 |
| Abstract: Kaposi sarcoma-associated herpesvirus (KSHV) is consistently found in biopsy samples from patients with AIDS-related and ''classical'' Kaposi's sarcoma.(KS). Although highly suggestive of a causal role of KSHV in the pathogenesis of KS, this observation does not exclude the possibility that KSHV, like other herpesviruses, is widely distributed and is a mere ''passenger'' in these lesions. Here we report that KSHV was detectable in peripheral blood mononuclear cells of 24/46 (52%) of KS patients, but in none of 134 blood donors or 26 HIV-uninfected hospital controls. KSHV detection increased with immunosuppression, as shown by a correlation with a reduced number of CD4-positive T-cells. Moreover, KSHV detection in peripheral blood cells of HIV-infected individuals without KS predicted the subsequent appearance of KS lesions. 143 patients who did not have KS at the time of their first (or only) blood sample were followed up for a median of 30 months. Of the 11 who had been KSHV positive 6 developed KS compared with only 12 out of 132 who were KSHV negative.
These findings are compatible with a causative role of KSHV in KS. KSHV was rarely detected in sputum and throat swabs of HIV-infected patients, providing a potential explanation for the apparently limited spread of this virus.
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| Document Type: Article |
| Language: English |
Addresses:
1. INST CANC RES, VIROL LAB, LONDON SW3 6BJ, ENGLAND
2. UCL, SCH MED, DIV VIROL, LONDON, ENGLAND
3. UCL, SCH MED, ACAD DEPT GENITOURINARY MED, LONDON, ENGLAND |
| Publisher: LANCET LTD, 42 BEDFORD SQUARE, LONDON, ENGLAND WC1B 3SL |
| Subject Category: Medicine, General & Internal |
| IDS Number: RW258 |
| ISSN: 0099-5355 |
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