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| QUANTITATIVE TRAIT LOCI ASSOCIATED WITH THE BEHAVIORAL-RESPONSE OF BXD RECOMBINANT INBRED MICE TO RESTRAINT STRESS - A PRELIMINARY COMMUNICATION |
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| Author(s): TARRICONE BJ, HINGTGEN JN, BELKNAP JK, MITCHELL SR, NURNBERGER JI |
| Source: BEHAVIOR GENETICS Volume: 25 Issue: 5 Pages: 489-495 Published: SEP 1995 |
| Times Cited: 20 References: 23 |
| Abstract: Quantitative trait loci (QTL) analysis was used to make provisional identification of loci containing genes influencing vulnerability to stress. The effect of restraint stress on open-field activity was measured in C57BL/6J and DBA/2J inbred strains of mice and in 22 BXD recombinant inbred strains of mice. QTL analyses were performed by correlating the behavioral delta scores for each group with the strain distribution pattern of 1300 markers for the BXD mice. A significant association was found between postrestraint rearings during min 5 through 8 in the open field and the Lamb2 marker on chromosome 1 (r = .718, p < .0001). Significant associations at the p < .0001 level were also found between baseline open-field rearings of control mice during min 0 through 5 and the Zp3, Ache, and Mr66-1 markers on chromosome 5, baseline open-field rearings of control mice during min 5 through 8 and the Pmv42 marker on chromosome 15, and open-field rearings of experimental mice during min 0 through 5 and the D11Ncvs61 marker on chromosome 11. |
| Document Type: Article |
| Language: English |
| Reprint Address: TARRICONE, BJ (reprint author), INDIANA UNIV, SCH MED, INST PSYCHIAT RES, DEPT PSYCHIAT, INDIANAPOLIS, IN 46202 USA |
Addresses:
1. INDIANA UNIV, SCH MED, PROGRAM MED NEUROBIOL, INDIANAPOLIS, IN 46202 USA
2. OREGON HLTH SCI UNIV, VET AFFAIRS MED CTR, RES SERV, PORTLAND, OR 97201 USA
3. OREGON HLTH SCI UNIV, DEPT MED PSYCHOL, PORTLAND, OR 97201 USA |
| Publisher: PLENUM PUBL CORP, 233 SPRING ST, NEW YORK, NY 10013 |
| Subject Category: Behavioral Sciences; Genetics & Heredity; Psychology, Multidisciplinary |
| IDS Number: RW362 |
| ISSN: 0001-8244 |
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