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| HUMAN RECOMBINANT STEM-CELL FACTOR INDUCES MELANOCYTIC HYPERPLASIA IN SUSCEPTIBLE PATIENTS |
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| Author(s): GRICHNIK JM, CRAWFORD J, JIMENEZ F, KURTZBERG J, BUCHANAN M, BLACKWELL S, CLARK RE, HITCHCOCK MG |
| Source: JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY Volume: 33 Issue: 4 Pages: 577-583 Published: OCT 1995 |
| Times Cited: 36 References: 27 |
| Abstract: Background: Recombinant human stem-cell factor (SCF), a cytokine acting on hematopoietic progenitor cells, has potential for the treatment of several hematologic and oncologic disorders. In a hematology-oncology phase I trial of SCF, several patients had cutaneous hyperpigmentation at the SCF subcutaneous injection sites. Objective: Our purpose was to investigate the pathogenesis of this hyperpigmentation phenomenon.
Methods: Skin biopsy specimens were obtained before, at the completion of, and after SCF therapy and were processed for histology, immunohistology, and electron microscopy.
Results: Skin at the site of SCF injection had an increased number of melanocytes, increased melanocytic dendrite extension, and melanin as compared with noninjected tissue. Immunohistochemical stains revealed an increase in staining with melanocyte-specific monoclonal antibodies HMB-45 and NKI/beteb, and a monoclonal antibody to the receptor for SCE c-kit.
Conclusion: Subcutaneous injection of SCF results in hyperplasia of melanocytes. SCF may be useful in the treatment of melanocytopenic disorders, but caution may be necessary in patients with disorders of melanocyte proliferation.
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| Document Type: Article |
| Language: English |
Addresses:
1. DUKE UNIV, MED CTR, DEPT MED, DIV DERMATOL, DURHAM, NC 27706 USA
2. DUKE UNIV, MED CTR, DEPT MED, DIV HEMATOL & MED ONCOL, DURHAM, NC 27706 USA
3. DUKE UNIV, MED CTR, DEPT PEDIAT, DURHAM, NC 27706 USA
4. DUKE UNIV, MED CTR, DEPT PATHOL, DURHAM, NC 27706 USA |
| Publisher: MOSBY-YEAR BOOK INC, 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 |
| Subject Category: Dermatology |
| IDS Number: RX311 |
| ISSN: 0190-9622 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |