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| THE ROLE OF NEUROPEPTIDE-Y IN THE ANTIOBESITY ACTION OF THE OBESE GENE-PRODUCT |
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| Author(s): STEPHENS TW, BASINSKI M, BRISTOW PK, BUEVALLESKEY JM, BURGETT SG, CRAFT L, HALE J, HOFFMANN J, HSIUNG HM, KRIAUCIUNAS A, MACKELLAR W, ROSTECK PR, SCHONER B, SMITH D, TINSLEY FC, ZHANG XY, HEIMAN M |
| Source: NATURE Volume: 377 Issue: 6549 Pages: 530-532 Published: OCT 12 1995 |
| Times Cited: 1,193 References: 12 |
| Abstract: RECENTLY Zhang et al.(1) cloned a gene that is expressed only in adipose tissue of tbe mouse. The obese phenotype of the ob/ob mouse is linked to a mutation in the obese gene that results in expression of a truncated inactive protein. Human and rat homologues for this gene are known(1,2). Previous experiments(3,4) predict such a hormone to have a hypothalamic target. Hypothalamic neuropeptide Y stimulates food intake, decreases thermogenesis, and increases plasma insulin and corticosterone levels making it a potential target(5). Here we express the obese protein in Escherichia coli and find that it suppresses food intake and decreases body weight dramatically when administered to normal and ob/ob mice but not db/db (diabetic) mice, which are thought to lack the appropriate receptor. High-affinity binding was detected in the rat hypothalamus. One mechanism by which this protein regulated food intake and metabolism was inhibition of neuropeptide-Y synthesis and release. |
| Document Type: Article |
| Language: English |
| Reprint Address: STEPHENS, TW (reprint author), ELI LILLY & CO, LILLY RES LABS, DIV ENDOCRINE RES, INDIANAPOLIS, IN 46285 USA |
Addresses:
1. ELI LILLY & CO, LILLY RES LABS, DIV TECHNOL CORE, INDIANAPOLIS, IN 46285 USA |
| Publisher: MACMILLAN MAGAZINES LTD, 4 LITTLE ESSEX STREET, LONDON, ENGLAND WC2R 3LF |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: RZ336 |
| ISSN: 0028-0836 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |