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| THE MINIMAL GENE COMPLEMENT OF MYCOPLASMA-GENITALIUM |
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| Author(s): FRASER CM, GOCAYNE JD, WHITE O, ADAMS MD, CLAYTON RA, FLEISCHMANN RD, BULT CJ, KERLAVAGE AR, SUTTON G, KELLEY JM, FRITCHMAN JL, WEIDMAN JF, SMALL KV, SANDUSKY M, FUHRMANN J, NGUYEN D, UTTERBACK TR, SAUDEK DM, PHILLIPS CA, MERRICK JM, TOMB JF, DOUGHERTY BA, BOTT KF, HU PC, LUCIER TS, PETERSON SN, SMITH HO, HUTCHISON CA, VENTER JC |
| Source: SCIENCE Volume: 270 Issue: 5235 Pages: 397-403 Published: OCT 20 1995 |
| Times Cited: 1,492 References: 59 |
| Abstract: The complete nucleotide sequence (580,070 base pairs) of the Mycoplasma genitalium genome, the smallest known genome of any free-living organism, has been determined by whole-genome random sequencing and assembly. A total of only 470 predicted coding regions were identified that include genes required for DNA replication, transcription and translation, DNA repair, cellular transport, and energy metabolism. Comparison of this genome to that of Haemophilus influenzae suggests that differences in genome content are reflected as profound differences in physiology and metabolic capacity between these two organisms. |
| Document Type: Article |
| Language: English |
| Reprint Address: FRASER, CM (reprint author), INST GENOM RES, 9712 MED CTR DR, ROCKVILLE, MD 20850 USA |
Addresses:
1. SUNY BUFFALO, DEPT MICROBIOL, BUFFALO, NY 14214 USA
2. JOHNS HOPKINS UNIV, SCH MED, BALTIMORE, MD 21205 USA
3. UNIV N CAROLINA, SCH MED, CHAPEL HILL, NC 27599 USA |
| Publisher: AMER ASSOC ADVAN SCIENCE, 1333 H ST NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: TA374 |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |