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| NULL MUTATION OF DLX-2 RESULTS IN ABNORMAL MORPHOGENESIS OF PROXIMAL FIRST AND 2ND BRANCHIAL ARCH DERIVATIVES AND ABNORMAL DIFFERENTIATION IN THE FOREBRAIN |
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| Author(s): QIU MS, BULFONE A, MARTINEZ S, MENESES JJ, SHIMAMURA K, PEDERSEN RA, RUBENSTEIN JLR |
| Source: GENES & DEVELOPMENT Volume: 9 Issue: 20 Pages: 2523-2538 Published: OCT 15 1995 |
| Times Cited: 217 References: 65 |
| Abstract: Genetic analysis of the development and evolution of the vertebrate head is at a primitive stage. Many homeo box genes, including the Distal-less family, are potential regulators of head development. To determine the function of DIx-2, we generated a null mutation in mice using gene targeting. In homozygous mutants, differentiation within the forebrain is abnormal and the fate of a subset of cranial neural crest cells is respecified. The latter causes abnormal morphogenesis of the skeletal elements derived from the proximal parts of the first and second branchial arches. We hypothesize that the affected skull bones from the first arch have undergone a transformation into structures similar to those found in reptiles. These results show that Dlx-2 controls development of the branchial arches and the forebrain and suggests its role in craniofacial evolution. |
| Document Type: Article |
| Language: English |
Addresses:
1. UNIV CALIF SAN FRANCISCO, DEPT PSYCHIAT, CTR NEUROBIOL & PSYCHIAT, NINA IRELAND LAB DEV NEUROBIOL, SAN FRANCISCO, CA 94143 USA
2. UNIV CALIF SAN FRANCISCO, PROGRAM NEUROSCI, SAN FRANCISCO, CA 94143 USA
3. UNIV CALIF SAN FRANCISCO, PROGRAM DEV BIOL, SAN FRANCISCO, CA 94143 USA
4. UNIV MURCIA, FAC MED, DEPT ANAT, E-30100 MURCIA, SPAIN
5. UNIV CALIF SAN FRANCISCO, RADIOBIOL & ENVIRONM HLTH LAB, SAN FRANCISCO, CA 94143 USA |
| Publisher: COLD SPRING HARBOR LAB PRESS, 1 BUNGTOWN RD, PLAINVIEW, NY 11724 |
| Subject Category: Cell Biology; Developmental Biology; Genetics & Heredity |
| IDS Number: TA967 |
| ISSN: 0890-9369 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |