| PAX GENES - WHATS NEW IN DEVELOPMENTAL BIOLOGY AND CANCER |
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| Author(s): STUART ET, GRUSS P |
| Source: HUMAN MOLECULAR GENETICS Volume: 4 Special Issue: Sp. Iss. SI Pages: 1717-1720 Published: 1995 |
| Times Cited: 49 References: 52 |
| Abstract: PAX genes encode nuclear transcription factors which are rapidly becoming regarded as major controllers of developmental processes in both vertebrates and invertebrates. Mutations in murine Pax genes underlie three natural mouse alleles and two corresponding human syndromes. Murine Pax genes have been shown to be proto-oncogenes. Furthermore, human PAX genes have recently been demonstrated to play an influential part in some common human cancers. The diversity in effects of PAX genes reflects that of their structure. All encode a DNA-binding domain termed the paired domain and in addition some also encode a second binding domain-the paired type-homeobox. |
| Document Type: Review |
| Language: English |
| Reprint Address: STUART, ET (reprint author), MAX PLANCK INST BRAIN RES, DEPT MOLEC CELL BIOL, FASSBERG, D-37077 GOTTINGEN, GERMANY |
| Publisher: OXFORD UNIV PRESS UNITED KINGDOM, WALTON ST JOURNALS DEPT, OXFORD, ENGLAND OX2 6DP |
| Subject Category: Biochemistry & Molecular Biology; Genetics & Heredity |
| IDS Number: TC033 |
| ISSN: 0964-6906 |