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| LOSS OF THE CHROMOSOMAL REGION 10Q23-25 IN PROSTATE-CANCER |
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| Author(s): GRAY IC, PHILLIPS SMA, LEE SJ, NEOPTOLEMOS JP, WEISSENBACH J, SPURR NK |
| Source: CANCER RESEARCH Volume: 55 Issue: 21 Pages: 4800-4803 Published: NOV 1 1995 |
| Times Cited: 183 References: 21 |
| Abstract: Loss of the chromosomal region 10q23-25 is a frequent event in the progression of prostate adenocarcinoma. A candidate tumor suppressor gene from this region, A Mxi1 at 10q25, has recently been shown to be mutated in a small number of prostate tumors, To more strictly define those regions of 10q loss that are likely to be involved in tumor advancement, we have constructed a detailed deletion map spanning 10q23-25 that incorporates Mxi1. Sixty-two % (23 of 37) of tumors analyzed exhibited some degree of 10q23-25 loss, Our data suggest the presence of a prostate tumor suppressor gene(s) near the 10q23-24 boundary, which was deleted in the overwhelming majority (22 of 23) of tumors showing loss, In contrast, specific loss of Mxi1, as opposed to loss of other 10q23-25 regions or of the entire region, was observed in only 1 of 23 tumors and was accompanied by loss of markers at the 10q23-24 boundary. Furthermore, we failed to detect any mutations in Mxi1 in those tumors shelving Mxi1-associated marker loss by either single-strand conformation polymorphism analysis or direct DNA sequencing. |
| Document Type: Note |
| Language: English |
| Reprint Address: GRAY, IC (reprint author), IMPERIAL CANC RES FUND, CLARE HALL LABS, POTTERS BAR EN6 3LD, HERTS ENGLAND |
Addresses:
1. QUEEN ELIZABETH HOSP, DEPT SURG, BIRMINGHAM B15 2TH, W MIDLANDS ENGLAND
2. ST MARYS HOSP WOMEN & CHILDREN, CENT MANCHESTER HEALTHCARE NATL HLTH SERV TRUST, MANCHESTER M13 0JH, LANCS ENGLAND
3. GENETHON SA, F-91000 EVRY, FRANCE |
| Publisher: AMER ASSOC CANCER RESEARCH, 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA |
| Subject Category: Oncology |
| IDS Number: TC468 |
| ISSN: 0008-5472 |
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