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| TARGETED MUTATION IN THE FAS GENE CAUSES HYPERPLASIA IN PERIPHERAL LYMPHOID ORGANS AND LIVER |
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| Author(s): ADACHI M, SUEMATSU S, KONDO T, OGASAWARA J, TANAKA T, YOSHIDA N, NAGATA S |
| Source: NATURE GENETICS Volume: 11 Issue: 3 Pages: 294-300 Published: NOV 1995 |
| Times Cited: 284 References: 51 |
| Abstract: Fas, a type I membrane protein that transduces an apoptotic signal, is expressed in lymphocytes as well as in various tissues such as the liver, lung and heart. The mouse lymphoproliferation (lpr) mutation is a leaky mutation in Fas. By means of gene targeting, we generated a mouse strain which is completely deficient in Fas. In addition to the massive production of lymphocytes, the Fas-null mice showed substantial liver hyperplasia, which was accompanied by the enlargement of nuclei in hepatocytes. The Fas system seems to play a role in the apoptotic process to maintain homeostasis of the liver as well as the peripheral lymphoid organs. |
| Document Type: Article |
| Language: English |
Addresses:
1. OSAKA BIOSCI INST, SUITA, OSAKA 565 JAPAN
2. OSAKA MED CTR MATERNAL & CHILD HLTH, IZUMI, OSAKA 59002 JAPAN |
| Publisher: NATURE PUBLISHING CO, 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 |
| Subject Category: Genetics & Heredity |
| IDS Number: TC639 |
| ISSN: 1061-4036 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |