| | |  | | | | Record from Web of Science® | | | | | | |
| AN INTERNATIONAL 2-STAGE GENOME-WIDE SEARCH FOR SCHIZOPHRENIA SUSCEPTIBILITY GENES |
|
|
| Author(s): MOISES HW, YANG L, KRISTBJARNARSON H, WIESE C, BYERLEY W, MACCIARDI F, AROLT V, BLACKWOOD D, LIU X, SJOGREN S, ASCHAUER HN, HWU HG, JANG K, LIVESLEY WJ, KENNEDY JL, ZOEGA T, IVARSSON O, BUI MT, YU MH, HAVSTEEN B, COMMENGES D, WEISSENBACH J, SCHWINGER E, GOTTESMAN II, PAKSTIS AJ, WETTERBERG L, KIDD KK, HELGASON T |
| Source: NATURE GENETICS Volume: 11 Issue: 3 Pages: 321-324 Published: NOV 1995 |
| Times Cited: 294 References: 20 |
| Abstract: Schizophrenia is thought to be a multifactorial disease with complex mode of inheritance (1,2). Using a two-stage strategy for another complex disorder, a number of putative IDDM-susceptibility genes have recently been mapped(3). We now report the results of a two-stage genome-wide search for genes conferring susceptibility to schizophrenia. In stage I, model-free linkage analyses of large pedigrees from Iceland, a geographical isolate, revealed 26 loci suggestive of linkage. In stage II, ten of these were followed-up in a second international collaborative study comprising families from Austria, Canada, Germany, Italy, Scotland, Sweden, Taiwan and the United States. Potential linkage findings of stage I on chromosomes 6p, 9 and 20 were observed again in the second sample. Furthermore, in a third sample from China, fine mapping of the 6p region by association studies also showed evidence for linkage or linkage disequilibrium. Combining our results with other recent findings(4,5) revealed significant evidence for linkage to an area distal of the HLA region on chromosome 6p. However, in a fourth sample from Europe, the 6p fine mapping finding observed in the Chinese sample could not be replicated. Finally evidence suggestive of locus heterogeneity and oligogenic transmission in schizophrenia was obtained. |
| Document Type: Letter |
| Language: English |
| Reprint Address: MOISES, HW (reprint author), UNIV HOSP KIEL, DEPT PSYCH, NIEMANNSWEG 147, D-24105 KIEL, GERMANY |
Addresses:
1. NATL UNIV HOSP REYKJAVIK, DEPT PSYCH, IS-121 REYKJAVIK, ICELAND
2. UNIV UTAH, DEPT PSYCH, SALT LAKE CITY, UT 84132 USA
3. UNIV MILAN, SCI INST HOSP ST RAFFAEL, DEPT NEUROSCI, I-20127 MILAN, ITALY
4. UNIV LUBECK, DEPT PSYCH, D-23538 LUBECK, GERMANY
5. UNIV EDINBURGH, DEPT PSYCH, EDINBURGH EH10 5HF, MIDLOTHIAN SCOTLAND
6. W CHINA UNIV MED SCI, DEPT PSYCH RES, CHENGDU 610041, PEOPLES R CHINA
7. KAROLINSKA INST, ST GORANS HOSP, DEPT PSYCH, S-11281 STOCKHOLM, SWEDEN
8. UNIV HOSP VIENNA, DEPT GEN PSYCH, A-1090 VIENNA, AUSTRIA
9. NATL TAIWAN UNIV HOSP, DEPT PSYCH, TAIPEI 100, TAIWAN
10. UNIV BRITISH COLUMBIA, DEPT PSYCH, VANCOUVER, BC V6T 2A1 CANADA
11. UNIV TORONTO, CLARKE INST PSYCH, TORONTO, ON M5T 1R8 CANADA
12. CHRISTIAN ALBRECHTS UNIV KIEL, DEPT BIOCHEM, D-24118 KIEL, GERMANY
13. UNIV BORDEAUX 2, INSERM, F-33077 BORDEAUX, FRANCE
14. GENETHON SA, F-91000 EVRY, FRANCE
15. UNIV LUBECK, DEPT HUMAN GENET, D-23538 LUBECK, GERMANY
16. UNIV VIRGINIA, DEPT PSYCH, CHARLOTTESVILLE, VA 22903 USA
17. YALE UNIV, SCH MED, DEPT GENET, NEW HAVEN, CT 06510 USA |
| Publisher: NATURE PUBLISHING CO, 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 |
| Subject Category: Genetics & Heredity |
| IDS Number: TC639 |
| ISSN: 1061-4036 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |