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| EVALUATION OF A SUSCEPTIBILITY GENE FOR SCHIZOPHRENIA ON CHROMOSOME 6P BY MULTIPOINT AFFECTED SIB-PAIR LINKAGE ANALYSIS |
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| Author(s): SCHWAB SG, ALBUS M, HALLMAYER J, HONIG S, BORRMANN M, LICHTERMANN D, EBSTEIN RP, ACKENHEIL M, LERER B, RISCH N, MAIER W, WILDENAUER DB |
| Source: NATURE GENETICS Volume: 11 Issue: 3 Pages: 325-327 Published: NOV 1995 |
| Times Cited: 216 References: 17 |
| Abstract: The influence of genetic factors in schizophrenia has been convincingly demonstrated by family, twin and adoption studies(1-3), but the mode of transmission remains uncertain. The reported pattern of recurrence risks suggests a set of interacting loci(4). Based on prior evidence for linkage on chromosome 6p (K. Kendler, pers. comm.), we have scanned the short arm of chromosome 6 in 54 families for loci predisposing to schizophrenia, using 25 microsatellite markers spanning 60 centiMorgans (cM). Allele sharing identity by descent was examined in affected sib-pairs from these families, followed by multipoint sib-pair linkage analysis. Positive lod scores were obtained over a wide region (D6S470 to D6S271), with a maximum lod score of 2.2 occuring near D6S274, located in 6p22. However, we obtained a lod score of -2 at D6S296, the locus found by others to provide the greatest linkage evidence(5). At D6S274, we report a positive lod score as do Straub et al.(5) (individually non-significant). A combined total lod of 3.6-4.0 suggests the possibility of a susceptibility locus in this region. However, methodological differences between our studies makes a firm conclusion difficult. |
| Document Type: Letter |
| Language: English |
Addresses:
1. UNIV MUNICH, HOSP PSYCHIAT, NEUROCHEM UNIT, D-80336 MUNICH, GERMANY
2. STATE MENTAL HOSP, D-85529 HAAR, GERMANY
3. STANFORD UNIV, DEPT GENET, STANFORD, CA 94305 USA
4. UNIV MAINZ, HOSP PSYCHIAT, D-55131 MAINZ, GERMANY
5. SARAH HERZOG HOSP, JERUSALEM, ISRAEL
6. HEBREW UNIV JERUSALEM, HADASSAH MED CTR, JERUSALEM, ISRAEL |
| Publisher: NATURE PUBLISHING CO, 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 |
| Subject Category: Genetics & Heredity |
| IDS Number: TC639 |
| ISSN: 1061-4036 |
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