| | |  | | | | Record from Web of Science® | | | | | | |
| ABERRANT SUBCELLULAR-LOCALIZATION OF BRCA1 IN BREAST-CANCER |
|
|
| Author(s): CHEN YM, CHEN CF, RILEY DJ, ALLRED DC, CHEN PL, VONHOFF D, OSBORNE CK, LEE WH |
| Source: SCIENCE Volume: 270 Issue: 5237 Pages: 789-791 Published: NOV 3 1995 |
| Times Cited: 240 References: 29 |
| Abstract: The BRCA1 gene product was identified as a 220-kilodalton nuclear phosphoprotein in normal cells, including breast ductal epithelial cells, and in 18 of 20 tumor cell lines derived from tissues other than breast and ovary. In 16 of 17 breast and ovarian cancer lines and 17 of 17 samples of cells obtained from malignant effusions, however, BRCA1 localized mainly in cytoplasm. Absence of BRCA1 or aberrant subcellular location was also observed to a variable extent in histological sections of many breast cancer biopsies. These findings suggest that BRCA1 abnormalities may be involved in the pathogenesis of many breast cancers, sporadic as well as familial. |
| Document Type: Article |
| Language: English |
Addresses:
1. UNIV TEXAS, HLTH SCI CTR, CTR MOLEC MED, INST BIOTECHNOL, SAN ANTONIO, TX 78245 USA
2. UNIV TEXAS, HLTH SCI CTR, DEPT PATHOL, SAN ANTONIO, TX 78284 USA
3. UNIV TEXAS, HLTH SCI CTR, DEPT MED, DIV MED ONCOL, SAN ANTONIO, TX 78284 USA |
| Publisher: AMER ASSOC ADVAN SCIENCE, 1333 H ST NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: TC712 |
| ISSN: 0036-8075 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |