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| EPIDEMIOLOGIC-STUDY OF DOWNS-SYNDROME IN DENMARK, INCLUDING FAMILY STUDIES OF CHROMOSOMES AND DNA MARKERS |
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| Author(s): MIKKELSEN M, HALLBERG A, POULSEN H, FRANTZEN M, HANSEN J, PETERSEN MB |
| Source: DEVELOPMENTAL BRAIN DYSFUNCTION Volume: 8 Issue: 1 Pages: 4-12 Published: JAN-FEB 1995 |
| Times Cited: 27 References: 48 |
| Abstract: All cases of Down's syndrome in Demmark born or aborted after prenatal diagnosis between January 1, 1990 and March 31, 1993 were registered. In a population of 5 millions and a birth rate of about 60,000-65,000 births per year, 207 liveborn and 159 fetuses aborted after prenatal diagnosis were registered. Ten cases of translocation or isochromosome 21 (4.8%) and 7 mosaics (3.4%) were found among the newborn infants. All available families with a trisomic child (119 newborn infants) were studied by DNA markers to identify the origin of the extra chromosome. In 8.4% the extra chromosome was paternal. In cases of maternal meiosis I and II errors maternal age was increased (mean 30.6 years). In paternal cases and mitotic cases no maternal age effect was observed (mean 28.0 and 26.8 years). The sex ratio was distorted especially in paternal errors and maternal meiosis II errors. |
| Document Type: Article |
| Language: English |
| Reprint Address: MIKKELSEN, M (reprint author), JOHN F KENNEDY INST, DEPT MED GENET, 7, GIL LANDEVEJ, DK-2600 GLOSTRUP, DENMARK |
Addresses:
1. CYTOGENET CENT REGISTER, RISSKOV, DENMARK |
| Publisher: KARGER, ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND |
| Subject Category: Developmental Biology; Neurosciences |
| IDS Number: TD388 |
| ISSN: 1019-5815 |
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