| | |  | | | | Record from Web of Science® | | | | | | |
| AGING AND CANCER - ARE TELOMERES AND TELOMERASE THE CONNECTION |
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| Author(s): SHAY JW |
| Source: MOLECULAR MEDICINE TODAY Volume: 1 Issue: 8 Pages: 378-384 Published: NOV 1995 |
| Times Cited: 95 References: 40 |
| Abstract: There is a substantial evidence for the progressive loss of the telomeric ends of chromosomes during , both in cell culture and in vivo. The loss of telomeres may eventually induce antiproliferative signals that result in cellular senescence. A hypothesis gaining prominence is that the activation of telomerase, a ribonucleoprotein enzyme that is important in maintaining telomere length stability, is necessary for the sustained growth of most tumors. The interrelationships between telomere shortening and aging, and how activation of telomerase may be necessary for cells to become immortal and malignant, are reviewed here. |
| Document Type: Review |
| Language: English |
| Reprint Address: SHAY, JW (reprint author), UNIV TEXAS, SW MED CTR, DEPT CELL BIOL & NEUROSCI, 5323 HARRY HINES BLVD, DALLAS, TX 75235 USA |
| Publisher: ELSEVIER SCI LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology; Medicine, Research & Experimental |
| IDS Number: TD676 |
| ISSN: 1357-4310 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |