| GUIDELINES FOR PROTEIN DESIGN - THE ENERGETICS OF BETA-SHEET SIDE-CHAIN INTERACTIONS |
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| Author(s): SMITH CK, REGAN L |
| Source: SCIENCE Volume: 270 Issue: 5238 Pages: 980-982 Published: NOV 10 1995 |
| Times Cited: 187 References: 23 |
| Abstract: To determine the interaction energy between cross-strand pairs of side chains on an antiparallel beta sheet, pairwise amino acid substitutions were made on the solvent-exposed face of the B1 domain of streptococcal protein G, The measured interaction energies were substantial (1.8 kilocalories per mole) and comparable to the magnitude of the beta sheet propensities. The experimental results paralleled the statistical frequency with which the residue pairs are found in beta sheets of known structure. |
| Document Type: Article |
| Language: English |
Addresses:
1. YALE UNIV, DEPT MOLEC BIOPHYS & BIOCHEM, NEW HAVEN, CT 06520 USA |
| Publisher: AMER ASSOC ADVAN SCIENCE, 1333 H ST NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: TD878 |
| ISSN: 0036-8075 |