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| GENOMIC STRUCTURE OF AN ATTENUATED QUASI-SPECIES OF HIV-1 FROM A BLOOD-TRANSFUSION DONOR AND RECIPIENTS |
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| Author(s): DEACON NJ, TSYKIN A, SOLOMON A, SMITH K, LUDFORDMENTING M, HOOKER DJ, MCPHEE DA, GREENWAY AL, ELLETT A, CHATFIELD C, LAWSON VA, CROWE S, MAERZ A, SONZA S, LEARMONT J, SULLIVAN JS, CUNNINGHAM A, DWYER D, DOWTON D, MILLS J |
| Source: SCIENCE Volume: 270 Issue: 5238 Pages: 988-991 Published: NOV 10 1995 |
| Times Cited: 734 References: 40 |
| Abstract: A blood donor infected with human immunodeficiency virus-type 1 (HIV-1) and a cohort of six blood or blood product recipients infected from this donor remain free of HIV-1-related disease with stable and normal CD4 lymphocyte counts 10 to 14 years after infection. HIV-1 sequences from either virus isolates or patient peripheral blood mononuclear cells had similar deletions in the nef gene and in the region of overlap of nef and the U3 region of the long terminal repeat (LTR). Full-length sequencing of one isolate genome and amplification of selected HIV-1 genome regions from other cohort members revealed no other abnormalities of obvious functional significance. These data show that survival after HIV infection can be determined by the HIV genome and support the importance of nef or the U3 region of the LTR in determining the pathogenicity of HIV-1. |
| Document Type: Article |
| Language: English |
| Reprint Address: DEACON, NJ (reprint author), MACFARLANE BURNET CTR MED RES, NATL CTR HIV VIROL RES, AIDS MOLEC BIOL UNIT, YARRA BEND RD, FAIRFIELD, VIC 3078 AUSTRALIA |
Addresses:
1. MACFARLANE BURNET CTR MED RES, NATL CTR HIV VIROL RES, AIDS CELLULAR BIOL UNIT, FAIRFIELD, VIC 3078 AUSTRALIA
2. MACFARLANE BURNET CTR MED RES, NATL CTR HIV VIROL RES, AIDS PATHOGENESIS UNIT, FAIRFIELD, VIC 3078 AUSTRALIA
3. NEW S WALES RED CROSS, BLOOD TRANSFUS SERV, SYDNEY 2000, NSW AUSTRALIA
4. WESTMEAD HOSP, DEPT VIROL, WESTMEAD, NSW 2145 AUSTRALIA
5. WESTMEAD HOSP, NATL CTR HIV VIROL RES, INST CLIN PATHOL & MED RES, WESTMEAD, NSW 2145 AUSTRALIA |
| Publisher: AMER ASSOC ADVAN SCIENCE, 1333 H ST NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: TD878 |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |