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| RECONSTITUTION OF I-KATP - AN INWARD RECTIFIER SUBUNIT PLUS THE SULFONYLUREA RECEPTOR |
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| Author(s): INAGAKI N, GONOI T, CLEMENT JP, NAMBA N, INAZAWA J, GONZALEZ G, AGUILARBRYAN L, SEINO S, BRYAN J |
| Source: SCIENCE Volume: 270 Issue: 5239 Pages: 1166-1170 Published: NOV 17 1995 |
| Times Cited: 1,145 References: 35 |
| Abstract: A member of the inwardly rectifying potassium channel family was cloned here. The channel, called BIR (Kir6.2), was expressed in large amounts in rat pancreatic islets and glucose-responsive insulin-secreting cell lines. Coexpression with the sulfonylurea receptor SUR reconstituted an inwardly rectifying potassium conductance of 76 picosiemens that was sensitive to adenosine triphosphate (ATP) (I-KATP) and was inhibited by sulfonylureas and activated by diazoxide. The data indicate that these pancreatic beta cell potassium channels are a complex composed of at least two subunits-BIR, a member of the inward rectifier potassium channel family, and SUR, a member of the ATP-binding cassette superfamily. Gene mapping data show that these two potassium channel subunit genes are clustered on human chromosome 11 at position 11p15.1. |
| Document Type: Article |
| Language: English |
Addresses:
1. CHIBA UNIV, SCH MED, CTR BIOMED SCI, DIV MOLEC MED, CHUO KU, CHIBA 260, JAPAN
2. CHIBA UNIV, PATHOGEN FUNGI & MICROBIAL TOXICOSES RES CTR, CHUO KU, CHIBA 260, JAPAN
3. BAYLOR COLL MED, DEPT CELL BIOL, HOUSTON, TX 77030 USA
4. BAYLOR COLL MED, DEPT MED, HOUSTON, TX 77030 USA
5. KYOTO PREFECTURAL UNIV MED, DEPT HYG, KAMIKYO KU, KYOTO 602, JAPAN |
| Publisher: AMER ASSOC ADVAN SCIENCE, 1333 H ST NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: TE905 |
| ISSN: 0036-8075 |
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