| | |  | | | | Record from Web of Science® | | | | | | |
| ASSOCIATION BETWEEN TUMOR ANGIOGENESIS AND TUMOR-CELL SHEDDING INTO EFFLUENT VENOUS-BLOOD DURING BREAST-CANCER SURGERY |
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| Author(s): MCCULLOCH P, CHOY A, MARTIN L |
| Source: LANCET Volume: 346 Issue: 8986 Pages: 1334-1335 Published: NOV 18 1995 |
| Times Cited: 67 References: 6 |
| Abstract: Tumour angiogenesis is a powerful prognostic indicator in breast cancer. Shedding of tumour cells into the bloodstream is essential for haematogenous metastasis. The relation between cell shedding and angiogenesis in human cancer is not known. We studied vascular density and cell shedding in 16 women undergoing breast cancer surgery. Circulating cells were found in one patient before, in six during, acid none after operation. Vascular density was related to detection of circulating tumour cells during surgery (correlation coefficient for first intraoperative sampling=0.56, p=0.024, 95% CI 0.08 to 0.83). Tumour cell shedding during surgery is related to vascular density; the relevance of this relation to the prognostic significance of vascular density in breast cancer merits further study. |
| Document Type: Note |
| Language: English |
| Reprint Address: MCCULLOCH, P (reprint author), ROYAL LIVERPOOL UNIV HOSP, DEPT SURG, LIVERPOOL L7 8XP, MERSEYSIDE ENGLAND |
| Publisher: LANCET LTD, 42 BEDFORD SQUARE, LONDON, ENGLAND WC1B 3SL |
| Subject Category: Medicine, General & Internal |
| IDS Number: TE916 |
| ISSN: 0099-5355 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |