| ORIGIN OF BILATERIAN BODY PLANS - EVOLUTION OF DEVELOPMENTAL REGULATORY MECHANISMS |
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| Author(s): DAVIDSON EH, PETERSON KJ, CAMERON RA |
| Source: SCIENCE Volume: 270 Issue: 5240 Pages: 1319-1325 Published: NOV 24 1995 |
| Times Cited: 251 References: 83 |
| Abstract: An argument is proposed to explain the origin of large metazoans, based on the regulatory processes that underlie the morphogenetic organization of pattern in modern animals. Genetic regulatory systems similar to those used in modern, indirectly developing marine invertebrates are considered to indicate the Precambrian regulatory platform on which were erected innovations that underlie the development of macroscopic body plans. Those systems are genetic regulatory programs that produce groups of unspecified ''set-aside cells'' and hierarchical regulatory programs that initially define regions of morphogenetic space in terms of domains of transcription factor expression, These ideas affect interpretation of the development of arthropods and chordates as well as interpretation of the role of the genes of the homeotic complex in embryogenesis. |
| Document Type: Article |
| Language: English |
| Reprint Address: DAVIDSON, EH (reprint author), CALTECH, DIV BIOL, PASADENA, CA 91125 USA |
Addresses:
1. UNIV CALIF LOS ANGELES, DEPT EARTH & SPACE SCI, LOS ANGELES, CA 90095 USA |
| Publisher: AMER ASSOC ADVAN SCIENCE, 1333 H ST NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: TF899 |
| ISSN: 0036-8075 |