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| A TRANSFORMING GROWTH-FACTOR-BETA RECEPTOR-TYPE-II GENE MUTATION COMMON IN COLON AND GASTRIC BUT RARE IN ENDOMETRIAL CANCERS WITH MICROSATELLITE INSTABILITY |
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| Author(s): MYEROFF LL, PARSONS R, KIM SJ, HEDRICK L, CHO KR, ORTH K, MATHIS M, KINZLER KW, LUTTERBAUGH J, PARK K, BANG YJ, LEE HY, PARK JG, LYNCH HT, ROBERTS AB, VOGELSTEIN B, MARKOWITZ SD |
| Source: CANCER RESEARCH Volume: 55 Issue: 23 Pages: 5545-5547 Published: DEC 1 1995 |
| Times Cited: 392 References: 25 |
| Abstract: We have recently demonstrated that mutation of the transforming growth factor-beta (TGF-beta) receptor type II (RII) gene is characteristic of colon cancers exhibiting microsatellite instability or replication errors (RER+), Moreover, we have shown that RII mutations in these RER+ colon cancers are characteristically frameshift mutations within a 10-bp polyadenine repeat present in the RII-coding region, We now show that RII gene mutations in this polyadenine repeat are also commonly present in RER+ gastric cancers (71%). In contrast, we find these same RII gene mutations are distinctly uncommon in RER+ endometrial cancers (17%, P < 0.02), These results suggest that RII gene mutations confer a growth advantage and are selected for in RER+ cancers of both the upper and lower gastrointestinal tract, The genesis of RER+ endometrial tumors must, however, be by a different route. |
| Document Type: Note |
| Language: English |
Addresses:
1. UNIV HOSP CLEVELAND, IRELAND CANC CTR, CLEVELAND, OH 44106 USA
2. CASE WESTERN RESERVE UNIV, DEPT MED, CLEVELAND, OH 44106 USA
3. JOHNS HOPKINS UNIV, DEPT PATHOL, BALTIMORE, MD 21231 USA
4. JOHNS HOPKINS UNIV, CTR ONCOL, BALTIMORE, MD 21231 USA
5. HOWARD HUGHES MED INST, CHEVY CHASE, MD 20815 USA
6. NCI, CHEMOPREVENT LAB, BETHESDA, MD 20892 USA
7. UNIV MICHIGAN, DIV MED & MOLEC GENET, ANN ARBOR, MI 48109 USA
8. UNIV TEXAS, SW MED SCH, SIMMONS CANC CTR, DALLAS, TX 75235 USA
9. SEOUL NATL UNIV, COLL MED, CANC RES CTR, SEOUL, SOUTH KOREA
10. CREIGHTON UNIV, SCH MED, DEPT PREVENT MED & PUBL HLTH, OMAHA, NE 68178 USA |
| Publisher: AMER ASSOC CANCER RESEARCH, PUBLIC LEDGER BLDG, SUITE 816, 150 S. INDEPENDENCE MALL W., PHILADELPHIA, PA 19106 |
| Subject Category: Oncology |
| IDS Number: TG211 |
| ISSN: 0008-5472 |
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