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| MOLECULAR-CLONING OF A NOVEL LAMININ CHAIN, ALPHA-5, AND WIDESPREAD EXPRESSION IN ADULT-MOUSE TISSUES |
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| Author(s): MINER JH, LEWIS RM, SANES JR |
| Source: JOURNAL OF BIOLOGICAL CHEMISTRY Volume: 270 Issue: 48 Pages: 28523-28526 Published: DEC 1 1995 |
| Times Cited: 195 References: 44 |
| Abstract: We have identified a fifth member of the alpha subfamily of vertebrate laminin chains. Sequence analysis revealed a close relationship of alpha 5 to the only known Drosophila alpha chain, suggesting that the ancestral alpha gene was more similar to alpha 5 than to alpha 1-4. Analysis of RNA expression showed that alpha 5 is widely expressed in adult tissues, with highest levels in lung, heart, and kidney. Our results suggest that alpha 5 may be a major laminin chain of adult basal laminae. |
| Document Type: Note |
| Language: English |
Addresses:
1. WASHINGTON UNIV, SCH MED, DEPT ANAT & NEUROBIOL, ST LOUIS, MO 63110 USA |
| Publisher: AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 |
| Subject Category: Biochemistry & Molecular Biology |
| IDS Number: TH056 |
| ISSN: 0021-9258 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |