| | |  | | | | Record from Web of Science® | | | | | | |
| GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE IS OVER-EXPRESSED DURING APOPTOTIC DEATH OF NEURONAL CULTURES AND IS RECOGNIZED BY A MONOCLONAL-ANTIBODY AGAINST AMYLOID PLAQUES FROM ALZHEIMERS BRAIN |
|
|
| Author(s): SUNAGA K, TAKAHASHI H, CHUANG DM, ISHITANI R |
| Source: NEUROSCIENCE LETTERS Volume: 200 Issue: 2 Pages: 133-136 Published: NOV 17 1995 |
| Times Cited: 65 References: 18 |
| Abstract: The age-induced apoptotic death of cerebellar neurons in culture is associated with over-expression of a 38-kDa particulate protein identified as glyceraldehyde-3-phosphate dehydrogenase (GAPDH). Both the age-induced apoptosis and the 38-kDa protein overexpression were effectively suppressed by the presence of tetrahydroaminoacridine, an antidementia drug, or aurintricarboxylic acid. This over-expressed 38-kDa protein and purified GAPDH were found to react with a monoclonal antibody (mAb), Am-3, which was raised against amyloid plaques from Alzheimer's brain, but not with a mAb, AmT-1, which was produced using synthetic amyloid beta peptide. These results raise the possibility that GAPDH is also involved in the neurodegeneration during the development of Alzheimer's disease. |
| Document Type: Article |
| Language: English |
Addresses:
1. JOSAI UNIV, CELLULAR NEUROBIOL GRP, SAKADO, SAITAMA 35002 JAPAN
2. TOKYO METROPOLITAN INST GERONTOL, DEPT PATHOL, ITABASHI KU, TOKYO 173, JAPAN
3. NIMH, BIOL PSYCHIAT BRANCH, MOLEC NEUROBIOL SECT, BETHESDA, MD 20892 USA |
| Publisher: ELSEVIER SCI PUBL IRELAND LTD, CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND |
| Subject Category: Neurosciences |
| IDS Number: TH950 |
| ISSN: 0304-3940 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |