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| LYSOSOMAL CHANGES IN RAT SPINAL GANGLIA NEURONS AFTER PROLONGED TREATMENT WITH CISPLATIN |
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| Author(s): STACCHIOTTI A, REZZANI R, RODELLA L, VENTURA RG |
| Source: ACTA ANATOMICA Volume: 153 Issue: 3 Pages: 236-242 Published: 1995 |
| Times Cited: 6 References: 38 |
| Abstract: We performed morphometric and ultrastructural studies to determine the morphological response of rat spinal ganglion sensory neurons to prolonged administration of cisplatin up to a total dose of 18 mg/kg. We quantitated the different types of lysosomal system (LS) bodies present (primary and secondary lysosomes, lipofuscin granules) as well as multivesicular bodies in treated and control animals. Five rats were examined per group. This ultrastructural study on cisplatin-induced changes in LS of spinal ganglia neurons shows that the total area and total number of LS structures are significantly increased by cisplatin treatment, The main specific changes were increase in number of small-size lysosomes and increase in number of polymeric lipofuscin granules, Other alterations observed were presence of nucleolar segregation, patches of neurofilaments and deposits of osmiophilic material in the perikaryon and axon hillock, all indicating that sensory neurons are a major target of cisplatin. |
| Document Type: Article |
| Language: English |
| Reprint Address: STACCHIOTTI, A (reprint author), UNIV BRESCIA, DEPT BIOMED SCI & BIOTECHNOL, HUMAN ANAT SECT, VIA VALSABBINA 19, I-25100 BRESCIA, ITALY |
| Publisher: KARGER, ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND |
| Subject Category: Anatomy & Morphology |
| IDS Number: TJ845 |
| ISSN: 0001-5180 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |