| EVOLUTION OF ATP-BINDING CASSETTE TRANSPORTER GENES |
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| Author(s): DEAN M, ALLIKMETS R |
| Source: CURRENT OPINION IN GENETICS & DEVELOPMENT Volume: 5 Issue: 6 Pages: 779-785 Published: DEC 1995 |
| Times Cited: 139 References: 42 |
| Abstract: The transport of molecules across lipid membranes is an essential function of all living organisms. One of the families of genes that have evolved to carry out this function is that which encodes the ATP-binding cassette proteins. These molecules use active transport to pump specific molecules across membranes, and the genes that encode them are found in abundance in the genomes of both prokaryotes and eukaryotes. By using gene disruption techniques and by studying homologous genes in model organisms, significant progress has been made during the last few years in evaluating the physiological functions of ABC proteins in higher eukaryotes. |
| Document Type: Article |
| Language: English |
| Reprint Address: DEAN, M (reprint author), NCI, FREDERICK CANC RES & DEV CTR, BLDG 560, ROOM 21-18, FREDERICK, MD 21702 USA |
| Publisher: CURRENT BIOLOGY LTD, 34-42 CLEVELAND STREET, LONDON, ENGLAND W1P 6LB |
| Subject Category: Cell Biology; Genetics & Heredity |
| IDS Number: TJ927 |
| ISSN: 0959-437X |