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| IDENTIFICATION OF THE BREAST-CANCER SUSCEPTIBILITY GENE BRCA2 |
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| Author(s): WOOSTER R, BIGNELL G, LANCASTER J, SWIFT S, SEAL S, MANGION J, COLLINS N, GREGORY S, GUMBS C, MICKLEM G, BARFOOT R, HAMOUDI R, PATEL S, RICE C, BIGGS P, HASHIM Y, SMITH A, CONNOR F, ARASON A, GUDMUNDSSON J, FICENEC D, KELSELL D, FORD D, TONIN P, BISHOP DT, SPURR NK, PONDER BAJ, EELES R, PETO J, DEVILEE P, CORNELISSE C, LYNCH H, NAROD S, LENOIR G, EGILSSON V, BARKADOTTIR RB, EASTON DF, BENTLEY DR, FUTREAL PA, ASHWORTH A, STRATTON MR |
| Source: NATURE Volume: 378 Issue: 6559 Pages: 789-792 Published: DEC 21 1995 |
| Times Cited: 1,510 References: 13 |
| Abstract: IN Western Europe and the United States approximately 1 in 12 women develop breast cancer. A small proportion of breast cancer cases, in particular those arising at a young age, are attributable to a highly penetrant, autosomal dominant predisposition to the disease. The breast cancer susceptibility gene, BRCA2, was recently localized to chromosome 13q12-q13. Here we report the identification of a gene in which we have detected six different germline mutations in breast cancer families that are likely to be due to BRCA2. Each mutation causes serious disruption to the open reading frame of the transcriptional unit. The results indicate that this is the BRCA2 gene. |
| Document Type: Article |
| Language: English |
| Reprint Address: WOOSTER, R (reprint author), INST CANC RES, HADDOW LABS, MOLEC CARCINOGENESIS SECT, 15 COTSWOLD RD, SUTTON SM2 5NG, SURREY ENGLAND |
Addresses:
1. INST CANC RES, HADDOW LABS, EPIDEMIOL SECT, SUTTON SM2 5NG, SURREY ENGLAND
2. INST CANC RES, HADDOW LABS, CRC CTR CELL & MOLEC BIOL, SUTTON SM2 5NG, SURREY ENGLAND
3. INST CANC RES, CHESTER BEATTY LABS, LONDON SW3 6JB, ENGLAND
4. NIEHS, MOLEC CARCINOGENESIS LAB, RES TRIANGLE PK, NC 27709 USA
5. SANGER CTR, HINXTON CB10 1RQ, CAMBS ENGLAND
6. DUKE UNIV, MED CTR, DEPT SURG, DURHAM, NC 27710 USA
7. DUKE UNIV, MED CTR, DEPT GENET, DURHAM, NC 27710 USA
8. DUKE UNIV, MED CTR, DIV GYNECOL ONCOL, DURHAM, NC 27710 USA
9. UNIV HOSP ICELAND, CELL BIOL LAB, IS-121 REYKJAVIK, ICELAND
10. IMPERIAL CANC RES FUND, CLARE HALL LABS, POTTERS BAR EN6 3LD, HERTS ENGLAND
11. MCGILL UNIV, DEPT MED, DIV MED GENET, MONTREAL, PQ H3G 1A4 CANADA
12. MCGILL UNIV, DEPT MED, DIV HUMAN GENET, MONTREAL, PQ H3G 1A4 CANADA
13. IMPERIAL CANC RES FUND, GENET EPIDEMIOL LAB, LEEDS LS2 9LU, W YORKSHIRE ENGLAND
14. ADDENBROOKES HOSP, CRC HUMAN CANC GENET RES GRP, CAMBRIDGE CB2 2QQ, ENGLAND
15. LEIDEN UNIV, DEPT HUMAN GENET & PATHOL, 2300 RA LEIDEN, NETHERLANDS
16. CREIGHTON UNIV, SCH MED, DEPT PREVENT MED & PUBL HLTH, OMAHA, NE 68178 USA
17. INT AGCY RES CANC, F-69372 LYON 08, FRANCE
18. UNIV CAMBRIDGE, INST PUBL HLTH, DEPT COMMUNITY MED, CRC GENET EPIDEMIOL GRP, CAMBRIDGE CB2 2SR, ENGLAND
19. WOMENS COLL HOSP, TORONTO, ON M5S 1B2 CANADA
20. WASHINGTON UNIV, SCH MED, CTR GENOME SEQUENCING, ST LOUIS, MO USA |
| Publisher: MACMILLAN MAGAZINES LTD, 4 LITTLE ESSEX STREET, LONDON, ENGLAND WC2R 3LF |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: TL419 |
| ISSN: 0028-0836 |
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