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| The Polycomb and trithorax group proteins of Drosophila: Trans-regulators of homeotic gene function |
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| Author(s): Kennison JA |
| Source: ANNUAL REVIEW OF GENETICS Volume: 29 Pages: 289-303 Published: 1995 |
| Times Cited: 237 References: 82 |
| Abstract: The Polycomb and trithorax group genes encode trans-regulators of homeotic gene function in Drosophila. The Polycomb group genes encode transcriptional repressors, while the trithorax group proteins are positive factors required for homeotic gene function. Among the Polycomb group proteins, the POLYCOMB protein has been most extensively characterized. The POLYCOMB protein contains a chromodomain, a conserved domain found in a Drosophila protein with effects on position-effect variegation. Among the trithorax group proteins characterized, the BRAHMA protein appears to be a subunit of a protein complex conserved from yeast to man (the SNF/SWI complex) that modifies chromatin to facilitate the transcriptional activation by gene-specific DNA-binding proteins. The ZESTE protein may help to activate transcription by bringing distant cis-regulatory elements closer to promoter-bound proteins. |
| Document Type: Review |
| Language: English |
| Reprint Address: Kennison, JA (reprint author), NICHHD, GENET MOLEC LAB, BETHESDA, MD 20892 USA |
| Publisher: ANNUAL REVIEWS INC, 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0139 |
| Subject Category: Genetics & Heredity |
| IDS Number: TL719 |
| ISSN: 0066-4197 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |