| | |  | | | | Record from Web of Science® | | | | | | |
| Lipofuscin of the retinal pigment epithelium: A review |
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| Author(s): Kennedy CJ, Rakoczy PE, Constable IJ |
| Source: EYE Volume: 9 Pages: 763-771 Part: Part 6 Published: 1995 |
| Times Cited: 119 References: 72 |
| Abstract: Accumulation of lipofuscin is one of the most characteristic features of ageing observed in retinal pigment epithelial (RPE) cells, The lipofuscin found in RPE cells differs from that of other body tissues due to the fact that it is mainly derived from the chemically modified residues of incompletely digested photoreceptor outer segments, It is a heterogeneous material composed of a mixture of lipids, proteins, and different fluorescent compounds, the main fluorophore of which has recently been identified as a derivative of vitamin A. Research interest has variously focussed on the roles of age, light damage, free radicals, antioxidants, visual pigments, retinal locus, lysosomal enzymes, and pigmentation on lipofuscin formation, as well. as the effects of lipofuscin on RPE cell function and causation of retinal disease. This article reviews the recent advances in knowledge of the composition, origin, and possible deleterious effects of RPE cell lipofuscin. |
| Document Type: Review |
| Language: English |
Addresses:
1. UNIV WESTERN AUSTRALIA, CTR OPHTHALMOL & VISUAL SCI, LIONS EYE INST, MOLEC BIOL UNIT, NEDLANDS, WA 6009 AUSTRALIA |
| Publisher: ROYAL COLL OPHTHALMOLOGISTS, 17 CORNWALL TERRACE, LONDON, ENGLAND NW1 4QW |
| Subject Category: Ophthalmology |
| IDS Number: TN696 |
| ISSN: 0950-222X |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |