| Progress in the development of mucosal vaccines based on Lactococcus lactis |
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| Author(s): Wells JM, Norton PM, LePage RWF |
| Source: INTERNATIONAL DAIRY JOURNAL Volume: 5 Issue: 8 Pages: 1071-1079 Published: 1995 |
| Times Cited: 11 References: 19 |
| Abstract: This paper reviews recent work on the construction and characterisation of recombinant strains of Lactococcus lactis which are able to express immunogens derived from e.g. Clostridium tetani, H.I.V. - 1 and Schistosoma mansoni. The immunogenicity of these constructs has been tested in mice. In some instances it has been possible to elicit protective level systemic immune responses as well as significant mucosal response following certain types of mucosal route vaccination. These studies and the key issues which have emerged from them are discussed. |
| Document Type: Proceedings Paper |
| Language: English |
| Reprint Address: Wells, JM (reprint author), UNIV CAMBRIDGE, DEPT PATHOL, TENNIS COURT RD, CAMBRIDGE CB2 1QP, ENGLAND |
| Publisher: ELSEVIER SCI LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB |
| Subject Category: Food Science & Technology |
| IDS Number: TP313 |
| ISSN: 0958-6946 |