| | |  | | | | Record from Web of Science® | | | | | | |
| Steps in tumor metastasis: New concepts from intravital videomicroscopy |
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| Author(s): Chambers AF, MacDonald IC, Schmidt EE, Koop S, Morris VL, Khokha R, Groom AC |
| Source: CANCER AND METASTASIS REVIEWS Volume: 14 Issue: 4 Pages: 279-301 Published: DEC 1995 |
| Times Cited: 145 References: 45 |
| Abstract: Metastases are responsible for the majority of failures in cancer treatment. Clarifying steps in metastasis and their molecular mechanisms will be important for the development of anti-metastasis therapeutic strategies. Considerable progress has been made in identifying molecules involved in metastasis. However, because of the nature of assays that have been available, conclusions about steps in metastasis and their molecular bases have been drawn primarily from inference. In order to complete the picture of how metastases form, a technique is needed to directly watch the process in vivo as it occurs over time. We have developed an intravital videomicroscopy (IVVM) procedure to make such observations possible. Results from IVVM are providing us with new conceptual understanding of the metastatic process, as well as the nature and timing of the contributions of molecules implicated in metastasis (e.g. adhesion molecules and proteinases). Our findings suggest that early steps in metastasis, including hemodynamic destruction and extravasation, may contribute less to metastatic inefficiency than previously believed. Instead, our results suggest that the control of post-extravasation growth of individual cancer cells is a significant contributor to metastatic inefficiency. Thus, this stage may be an appropriate target for design of novel strategies to prevent metastases. |
| Document Type: Review |
| Language: English |
| Reprint Address: Chambers, AF (reprint author), LONDON REG CANC CTR, 790 COMMISSIONERS RD E, LONDON, ON N6A 4L6 CANADA |
Addresses:
1. UNIV WESTERN ONTARIO, DEPT ONCOL, LONDON, ON N6A 4L6 CANADA
2. UNIV WESTERN ONTARIO, DEPT MED BIOPHYS, LONDON, ON N6A 4L6 CANADA
3. UNIV WESTERN ONTARIO, DEPT MICROBIOL & IMMUNOL, LONDON, ON N6A 4L6 CANADA
4. UNIV WESTERN ONTARIO, DEPT BIOCHEM, LONDON, ON N6A 4L6 CANADA
5. JOHN P ROBARTS RES INST, LONDON, ON N6A 4L6 CANADA |
| Publisher: KLUWER ACADEMIC PUBL, SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS |
| Subject Category: Oncology |
| IDS Number: TQ918 |
| ISSN: 0167-7659 |
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