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| Peptide-pulsed dendritic cells induce antigen-specific, CTL-mediated protective tumor immunity |
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| Author(s): Celluzzi CM, Mayordomo JI, Storkus WJ, Lotze MT, Falo LD |
| Source: JOURNAL OF EXPERIMENTAL MEDICINE Volume: 183 Issue: 1 Pages: 283-287 Published: JAN 1 1996 |
| Times Cited: 542 References: 44 |
| Abstract: Cytotoxic T lymphocytes (CTLs) are a critical component of the immune response to tumors. Tumor-derived peptide antigens targeted by CTLs are being defined for several human tumors and are potential immunogens for the induction of specific antitumor immunity. Dendritic cells (DC) are potent antigen-presenting cells (APCs) capable of priming CTL responses in vivo. Here we show that major histocompatibility complex class I-presented peptide antigen pulsed onto dendritic APCs induces protective immunity to lethal challenge by a tumor transfected with the antigen gene. The immunity is antigen specific, requiring expression of the antigen gene by the tumor target, and is eliminated by in vivo depletion of CD8(+) T cells. Furthermore, mice that have rejected the transfected tumor are protected from subsequent challenge with the untransfected parent tumor. These results suggest that immunization strategies using antigen-pulsed DC may be useful for inducing tumor-specific immune responses. |
| Document Type: Article |
| Language: English |
Addresses:
1. UNIV PITTSBURGH, SCH MED, DEPT DERMATOL, MED CTR, PITTSBURGH, PA 15213 USA
2. UNIV PITTSBURGH, MED CTR, DEPT SURG MOLEC GENET & BIOCHEM, PITTSBURGH, PA 15213 USA
3. UNIV PITTSBURGH, MED CTR, PITTSBURGH CANC INST, PITTSBURGH, PA 15213 USA |
| Publisher: ROCKEFELLER UNIV PRESS, 222 E 70TH STREET, NEW YORK, NY 10021 |
| Subject Category: Immunology; Medicine, Research & Experimental |
| IDS Number: TP365 |
| ISSN: 0022-1007 |
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