| | |  | | | | Record from Web of Science® | | | | | | |
| Interleukin 6 receptor antibody inhibits muscle atrophy and modulates proteolytic systems in interleukin 6 transgenic mice |
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| Author(s): Tsujinaka T, Fujita J, Ebisui C, Yano M, Kominami E, Suzuki K, Tanaka K, Katsume A, Ohsugi Y, Shiozaki H, Monden M |
| Source: JOURNAL OF CLINICAL INVESTIGATION Volume: 97 Issue: 1 Pages: 244-249 Published: JAN 1 1996 |
| Times Cited: 169 References: 54 |
| Abstract: The muscles of IL-6 transgenic mice suffer from atrophy. Experiments were carried out on these transgenic mice to elucidate activation of proteolytic systems in the gastrocnemius muscles and blockage of this activation by treatment with the anti-mouse IL-6 receptor (mIL-6R) antibody, Muscle atrophy observed in 16-wk-old transgenic mice was completely blocked by treatment with the mn-SR antibody. In association with muscle atrophy, enzymatic activities and mRNA levels of cathepsins (B and L) and mRNA levels of ubiquitins (poly- and mono-ubiquitins) increased, whereas the mRNA level of muscle-specific calpain (calpain 3) decreased. All these changes were completely eliminated by treatment with the mIL-6R antibody. This IL-6 receptor antibody could, therefore, be effective against muscle wasting in sepsis and cancer cachexia, where IL-S plays an important role. |
| Document Type: Article |
| Language: English |
| Reprint Address: Tsujinaka, T (reprint author), OSAKA UNIV, SCH MED, DEPT SURG 2, 2-2 YAMADAOKA, SUITA, OSAKA 565 JAPAN |
Addresses:
1. JUNTENDO UNIV, SCH MED, DEPT BIOCHEM, TOKYO 113, JAPAN
2. UNIV TOKYO, INST MOLEC & CELLULAR BIOSCI, TOKYO 113, JAPAN
3. UNIV TOKUSHIMA, INST ENZYME RES, TOKUSHIMA 770, JAPAN
4. CHUGAI PHARMACEUT CO LTD, FUJI GOTEMBA RES LABS, GOTEMBA 412, JAPAN |
| Publisher: ROCKEFELLER UNIV PRESS, 222 E 70TH STREET, NEW YORK, NY 10021 |
| Subject Category: Medicine, Research & Experimental |
| IDS Number: TQ105 |
| ISSN: 0021-9738 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |