| | |  | | | | Record from Web of Science® | | | | | | |
| Bone morphogenetic protein-1: The type I procollagen C-proteinase |
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| Author(s): Kessler E, Takahara K, Biniaminov L, Brusel M, Greenspan DS |
| Source: SCIENCE Volume: 271 Issue: 5247 Pages: 360-362 Published: JAN 19 1996 |
| Times Cited: 254 References: 30 |
| Abstract: Bone morphogenetic proteins (BMPs) are bone-derived factors capable of inducing ectopic bone formation. Unlike other BMPs, BMP-1 is not like transforming growth factor-beta (TGF-beta), but it is the prototype of a family of putative proteases implicated in pattern formation during development in diverse organisms. Although some members of this group, such as Drosophila tolloid (TLD), are postulated to activate TGF-beta-like proteins, actual substrates are unknown, Procollagen C-proteinase (PCP) cleaves the COOH-propeptides of procollagens I, II, and III to yield the major fibrous components of vertebrate extracellular matrix. Here it is shown that BMP-1 and PCP are identical. This demonstration of enzymatic activity for a BMP-1/TLD-like protein links an enzyme involved in matrix deposition to genes involved in pattern formation. |
| Document Type: Article |
| Language: English |
| Reprint Address: Kessler, E (reprint author), TEL AVIV UNIV, SACKLER FAC MED, CHAIM SHEBA MED CTR, MAURICE & GABRIELA GOLDSCHLEGER EYE RES INST, IL-52621 TEL HASHOMER, ISRAEL |
Addresses:
1. UNIV WISCONSIN, DEPT PATHOL & LAB MED, MADISON, WI 53706 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: TQ528 |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |