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| Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein |
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| Author(s): Brocke S, Gijbels K, Allegretta M, Ferber I, Piercy C, Blankenstein T, Martin R, Utz U, Karin N, Mitchell D, Veromaa T, Waisman A, Gaur A, Conlon P, Ling N, Fairchild PJ, Wraith DC, OGarra A, Fathman CG, Steinman L |
| Source: NATURE Volume: 379 Issue: 6563 Pages: 343-346 Published: JAN 25 1996 |
| Times Cited: 321 References: 21 |
| Abstract: FOLLOWING induction of experimental encephalomyelitis with a T-cell clone, L10C1, that is specific for the myelin basic protein epitope p87-99, the inflammatory infiltrate in the central nervous system contains a diverse collection of T cells with heterogeneous receptors. We show here that when clone L10C1 is tolerized in vivo with an analogue of p87-99, established paralysis is reversed, inflammatory infiltrates regress, and the heterogeneous T-cell infiltrate disappears from the brain, with only the T-cell clones that incited disease remaining in the original lesions. We found that antibody raised against interleukin-4 reversed the tolerance induced by the altered peptide ligand. Treatment,vith this altered peptide ligand selectively silences pathogenic T cells and actively signals for the efflux of other T cells recruited to the site of disease as a result of the production of interleukin-4 and the reduction of tumour-necrosis factor-alpha in the lesion. |
| Document Type: Article |
| Language: English |
Addresses:
1. STANFORD UNIV, MED CTR, DEPT NEUROL & NEUROL SCI, STANFORD, CA 94305 USA
2. STANFORD UNIV, MED CTR, DEPT MED, STANFORD, CA 94305 USA
3. STANFORD UNIV, MED CTR, DEPT PATHOL, STANFORD, CA 94305 USA
4. MAX DELBRUCK CTR MOLEC MED, D-13125 BERLIN, GERMANY
5. NINCDS, NEUROIMMUNOL BRANCH, BETHESDA, MD 20892 USA
6. WEIZMANN INST SCI, DEPT IMMUNOL, IL-76100 REHOVOT, ISRAEL
7. NEUROCRINE BIOSCI, LA JOLLA, CA 92121 USA
8. UNIV CAMBRIDGE, DEPT PATHOL, CAMBRIDGE CB1 1QP, ENGLAND
9. DNAX RES INST MOLEC & CELLULAR BIOL INC, PALO ALTO, CA 94305 USA |
| Publisher: MACMILLAN MAGAZINES LTD, 4 LITTLE ESSEX STREET, LONDON, ENGLAND WC2R 3LF |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: TR323 |
| ISSN: 0028-0836 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |