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| Fusion of the EWS gene to CHN, a member of the steroid thyroid receptor gene superfamily, in a human myxoid chondrosarcoma |
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| Author(s): Clark J, Benjamin H, Gill S, Sidhar S, Goodwin G, Crew J, Gusterson BA, Shipley J, Cooper CS |
| Source: ONCOGENE Volume: 12 Issue: 2 Pages: 229-235 Published: JAN 18 1996 |
| Times Cited: 106 References: 35 |
| Abstract: The specific chromosomal translocation t(9;22)(q22-31;q11-12) has been observed in the myxoid variant of human chondrosarcoma. In agreement with this observation we report that the EWS gene located at chromosome band 22q12 becomes fused to CHN, a member of the steroid/thyroid receptor gene superfamily located at 9q22-31, in a skeletal myxoid chondrosarcoma. CHN appears to be the human homologue of the rat gene NOR1, which was recently identified as a sequence overexpressed in rat brain cells undergoing apoptosis. Our results also indicate that the chimaeric EWS-CHN gene encodes a EWS-CHN fusion protein in which the C-terminal RNA-binding domain of EWS is replaced by the entire CHN protein, comprising a long N-terminal domain, a central DNA binding domain and a C-terminal ligand-binding/dimerisation domain. |
| Document Type: Article |
| Language: English |
Addresses:
1. INST CANC RES, HADDOW LABS, SECT MOLEC CARCINOGENESIS, SUTTON SM2 5NG, SURREY ENGLAND
2. INST CANC RES, HADDOW LABS, SECT CELL BIOL & EXPTL PATHOL, SUTTON SM2 5NG, SURREY ENGLAND
3. CHESTER BEATTY LABS, SECT CELL & MOLEC BIOL, LONDON SW3 6JB, ENGLAND |
| Publisher: STOCKTON PRESS, HOUNDMILLS, BASINGSTOKE, HAMPSHIRE, ENGLAND RG21 6XS |
| Subject Category: Biochemistry & Molecular Biology; Oncology; Cell Biology; Genetics & Heredity |
| IDS Number: TR538 |
| ISSN: 0950-9232 |
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