| | |  | | | | Record from Web of Science® | | | | | | |
| Reduction of lipoic acid by lipoamide dehydrogenase |
|
|
| Author(s): Biewenga GP, Dorstijn MA, Verhagen JV, Haenen GRMM, Bast A |
| Source: BIOCHEMICAL PHARMACOLOGY Volume: 51 Issue: 3 Pages: 233-238 Published: FEB 9 1996 |
| Times Cited: 23 References: 30 |
| Abstract: Racemic lipoic acid is therapeutically applied in pathologies in which free radicals are involved. The in vivo reduction of lipoic acid may play an essential role in its antioxidant effect. It was found that mitochondrial lipoamide dehydrogenase (LipDH, EC 1.8.1.4.) reduces the R-enantiomer 28 times faster than the S-enantiomer of lipoic acid. Moreover, it was observed that the metabolites of lipoic acid, bisnor-, tetranor-, and beta-lipoic acid are poor substrates of LipDH. S-lipoic acid inhibits the reduction of the R enantiomer only at relatively high concentrations. The reduction of R-lipoic acid by mitochondria-rich tissues may proceed smoothly, even if the racemic mixture is applied. This is of importance in elucidating the molecular mechanism of the pharmacotherapeutic effect of lipoic acid. |
| Document Type: Article |
| Language: English |
| Reprint Address: Biewenga, GP (reprint author), FREE UNIV AMSTERDAM, DEPT PHARMACOCHEM, LEIDEN AMSTERDAM CTR DRUG RES, DIV MOLEC PHARMACOL, 1081 HV AMSTERDAM, NETHERLANDS |
| Publisher: PERGAMON-ELSEVIER SCIENCE LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB |
| Subject Category: Pharmacology & Pharmacy |
| IDS Number: TR741 |
| ISSN: 0006-2952 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |