| | |  | | | | Record from Web of Science® | | | | | | |
| Graft-versus-myeloma effect: Proof of principle |
|
|
| Author(s): Tricot G, Vesole DH, Jagannath S, Hilton J, Munshi N, Barlogie B |
| Source: BLOOD Volume: 87 Issue: 3 Pages: 1196-1198 Published: FEB 1 1996 |
| Times Cited: 295 References: 26 |
| Abstract: The presence of a graft-versus-tumor effect has been well established in leukemia but not in multiple myeloma. A 40-year-old patient with myeloma refractory to standard chemotherapy and autologous transplantation received matched unrelated T-cell-depleted transplant after conditioning with fractionated total-body irradiation, thiotepa, and cyclophosphamide. This procedure resulted in a transient and incomplete response with evidence of rapidly progressive disease within 2.5 months posttransplantation. The patient then received a small number of donor peripheral blood (PB) mononuclear cells (CD3 cells 1.2 x 10(6)/kg) without any further cytotoxic therapy. A complete remission was attained, lasting now for more than 14 months. The procedure was associated with severe acute and subsequently limited chronic graft-versus-host disease (GVHD). This report provides the first direct evidence of a graft-versus-myeloma effect after allogeneic transplantation. (C) 1996 by The American Society of Hematology. |
| Document Type: Article |
| Language: English |
| Reprint Address: Tricot, G (reprint author), UNIV ARKANSAS MED SCI HOSP, DIV HEMATOL ONCOL, 4301 W MARKHAM, SLOT 508, LITTLE ROCK, AR 72205 USA |
Addresses:
1. UNIV ARKANSAS MED SCI HOSP, ARKANSAS CANC RES CTR, LITTLE ROCK, AR 72205 USA |
| Publisher: W B SAUNDERS CO, INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 |
| Subject Category: Hematology |
| IDS Number: TT484 |
| ISSN: 0006-4971 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |