| | |  | | | | Record from Web of Science® | | | | | | |
| Sonic hedgehog is expressed in epithelial cells during development of whisker, hair, and tooth |
|
|
| Author(s): Iseki S, Araga A, Ohuchi H, Nohno T, Yoshioka H, Hayashi F, Noji S |
| Source: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Volume: 218 Issue: 3 Pages: 688-693 Published: JAN 26 1996 |
| Times Cited: 77 References: 21 |
| Abstract: Sonic hedgehog (Shh) is a vertebrate gene homologous to a Drosophila segment polarity gene. hedgehog, and functions as a secreted signaling molecule in limb pattern formation. differentiation of motor neurons. and sclerotome induction. We found that Shh is also expressed in epithelia of the developing whisker, hair, tooth, rugae, and thyroid primordium of mouse embryos. In whisker and hair development. Shh is expressed in epithelial cells before condensation of the underlying mesenchymal cells and then in the placode. The expression of Shh continues in the hair bulb surrounding the dermal papilla. Shh is also expressed in epithelial cells of the tooth bud. then localized to the enamel knot. The Shh expression continues in developing ameloblasts. These results suggest that SHH is an essential epithelial signaling molecule in epithelio-mesenchymal interactions for the terminal differentiation. (C) 1996 Academic Press, Inc. |
| Document Type: Article |
| Language: English |
Addresses:
1. UNIV TOKUSHIMA, FAC ENGN, DEPT BIOL SCI & TECHNOL, TOKUSHIMA 770, JAPAN
2. UNIV TOKUSHIMA, SCH DENT, DEPT ORAL PATHOL, TOKUSHIMA 770, JAPAN
3. KAWASAKI MED UNIV, DEPT PHARMACOL, KURASHIKI, OKAYAMA 70101 JAPAN |
| Publisher: ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS, 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 |
| Subject Category: Biochemistry & Molecular Biology; Biophysics |
| IDS Number: TT598 |
| ISSN: 0006-291X |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |