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| The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9 |
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| Author(s): Borrow J, Shearman AM, Stanton VP, Becher R, Collins T, Williams AJ, Dube I, Katz F, Kwong YL, Morris C, Ohyashiki K, Toyama K, Rowley J, Housman DE |
| Source: NATURE GENETICS Volume: 12 Issue: 2 Pages: 159-167 Published: FEB 1996 |
| Times Cited: 274 References: 59 |
| Abstract: The t(7;11)(p15;p15) translocation is a recurrent chromosomal abnormality associated primarily with acute myeloid leukaemia (FAB M2 and M4). We present here the molecular definition of this translocation. On chromosome 7 positional cloning revealed the consistent rearrangement of the HOXA9 gene, which encodes a class I homeodomain protein potentially involved in myeloid differentiation. On chromosome 11 the translocation targets the human homologue of NUP98, a member of the GLFG nucleoporin family. Chimaeric messages spliced over the breakpoint fuse the GLFG Massachusetts repeat domains of NUP98 in-frame to the HOXA9 homeobox. The predicted NUP98-HOXA9 fusion protein may promote leukaemogenesis through inhibition of HOXA9-mediated terminal differentiation and/or aberrant nucleocytoplasmic transport. |
| Document Type: Article |
| Language: English |
| Reprint Address: Borrow, J (reprint author), MIT, CTR CANC RES, 77 MASSACHUSETTS AVE, CAMBRIDGE, MA 02139 USA |
Addresses:
1. W GERMAN CANC CTR, D-45122 ESSEN 1, GERMANY
2. BRIGHAM & WOMENS HOSP, DEPT PATHOL, BOSTON, MA 02115 USA
3. UNIV TORONTO, TORONTO, ON M5G 1L5 CANADA
4. GREAT ORMOND ST HOSP SICK CHILDREN, LONDON WC1N 1EH, ENGLAND
5. UNIV HONG KONG, QUEEN MARY HOSP, DEPT MED, HONG KONG, HONG KONG
6. CHRISTCHURCH SCH MED, CHRISTCHURCH, NEW ZEALAND
7. TOKYO MED COLL, SHINJUKU KU, TOKYO 160, JAPAN
8. UNIV CHICAGO, MED CTR, CHICAGO, IL 60637 USA |
| Publisher: NATURE PUBLISHING CO, 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 |
| Subject Category: Genetics & Heredity |
| IDS Number: TU079 |
| ISSN: 1061-4036 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |