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| Down's syndrome-like skeletal abnormalities in Ets2 transgenic mice |
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| Author(s): Sumarsono SH, Wilson TJ, Tymms MJ, Venter DJ, Corrick CM, Kola R, Lahoud MH, Papas TS, Seth A, Kola I |
| Source: NATURE Volume: 379 Issue: 6565 Pages: 534-537 Published: FEB 8 1996 |
| Times Cited: 131 References: 23 |
| Abstract: EXPRESSION of Ets2, a proto-oncogene(1) and transcription factor(2-5), occurs in a variety of cell types(6), During murine development it is highly expressed in newly forming cartilage, including In the skull precursor cells and vertebral primordia(7), Ets(2) is located on human chromosome 21 (ref. 8) and is overexpressed in Down's syndrome (trisomy 21)(9), Here we generate transgenic mice to Investigate the consequences of overexpression of Ets2, We find that mice with less than 2-fold Ets2 overexpression in particular organs develop neurocranial, viscerocranial and cervical skeletal abnormalities, These abnormalities have similarities with the skeletal anomalies found in trisomy-16 mice and humans with Down's syndrome, in which the gene dosage of Ets2 is increased(10,12), Our results indicate that Ets2 has a role in skeletal development and implicate the overexpression of Ets2 in the genesis of some skeletal abnormalities that occur in Down's syndrome. |
| Document Type: Article |
| Language: English |
Addresses:
1. MONASH UNIV, MONASH MED CTR, INST REPROD & DEV, MOLEC GENET & DEV GRP, CLAYTON, VIC 3168 AUSTRALIA
2. PETER MACCALLUM CANC INST, MELBOURNE, VIC 3002 AUSTRALIA
3. MED UNIV S CAROLINA, HOLLINGS CANC CTR, CTR MOLEC & STRUCT BIOL, CHARLESTON, SC 29425 USA
4. UNIV TORONTO, FAC MED, DEPT PATHOL, TORONTO, ON M5S 1A8 CANADA
5. UNIV TORONTO, FAC DENT, TORONTO, ON M5S 1A8 CANADA
6. WOMENS COLL HOSP, TORONTO, ON M5S 1A8 CANADA |
| Publisher: MACMILLAN MAGAZINES LTD, 4 LITTLE ESSEX STREET, LONDON, ENGLAND WC2R 3LF |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: TU693 |
| ISSN: 0028-0836 |
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