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| A genetic linkage map of the rat derived from recombinant inbred strains |
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| Author(s): Pravenec M, Gauguier D, Schott JJ, Buard J, Kren V, Bila V, Szpirer C, Szpirer J, Wang JM, Huang H, StLezin E, Spence MA, Flodman P, Printz M, Lathrop GM, Vergnaud G, Kurtz TW |
| Source: MAMMALIAN GENOME Volume: 7 Issue: 2 Pages: 117-127 Published: FEB 1996 |
| Times Cited: 95 References: 49 |
| Abstract: We have constructed a genetic linkage map in the rat by analyzing the strain distribution patterns of 500 genetic markers in a large set of recombinant inbred strains derived from the spontaneously hypertensive rat and the Brown-Norway rat (HXB and BXH recombinant inbred strains). 454 of the markers could be assigned to specific chromosomes, and the amount of genome covered by the mapped markers was estimated to be 1151 centimorgans. By including a variety of morphologic, biochemical, immunogenetic, and molecular markers, the current map integrates and extends existing linkage data and should facilitate rat gene mapping and genetic studies of hypertension and other complex phenotypes of interest in the HXB and BXH recombinant inbred strains. |
| Document Type: Article |
| Language: English |
| Reprint Address: Pravenec, M (reprint author), ACAD SCI CZECH REPUBL, INST PHYSIOL, VIDENSKA 1083, CR-14220 PRAGUE 4, CZECH REPUBLIC |
Addresses:
1. CTR ETUD BOUCHET, GENET MOLEC LAB, F-91710 VERT LE PETIT, FRANCE
2. WELLCOME TRUST CTR HUMAN GENET, OXFORD, ENGLAND
3. INST BIOL, LAB GENET ESPECES, NANTES, FRANCE
4. CHARLES UNIV, DEPT BIOL, FAC MED 1, PRAGUE, CZECH REPUBLIC
5. FREE UNIV BRUSSELS, DEPT BIOL MOLEC, B-1640 RHODE ST GENESE, BELGIUM
6. UNIV CALIF SAN FRANCISCO, DEPT LAB MED, SAN FRANCISCO, CA 94143 USA
7. UNIV CALIF SAN DIEGO, DEPT PHARMACOL, SAN DIEGO, CA 92103 USA
8. UNIV CALIF IRVINE, DEPT PEDIAT, IRVINE, CA 92717 USA
9. HOP ST LOUIS, INSERM U358, PARIS, FRANCE |
| Publisher: SPRINGER VERLAG, 175 FIFTH AVE, NEW YORK, NY 10010 |
| Subject Category: Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Genetics & Heredity |
| IDS Number: TV274 |
| ISSN: 0938-8990 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |