| | |  | | | | Record from Web of Science® | | | | | | |
| Characterization of a cancer cachectic factor |
|
|
| Author(s): Todorov P, Cariuk P, McDevitt T, Coles B, Fearon K, Tisdale M |
| Source: NATURE Volume: 379 Issue: 6567 Pages: 739-742 Published: FEB 22 1996 |
| Times Cited: 257 References: 17 |
| Abstract: CANCER cachexia is a syndrome of progressive wasting which has been suggested to be mediated by tumour-necrosis factor-alpha (ref. 1), interleukins 1 and 6 (ref. 2), interferon-gamma (ref. 3) and leukaemia-inhibitory factor(4). It has proved difficult to correlate levels of tumour-necrosis factor-alpha and interleukin-6 with cancer cachexia(5,6), and the weight loss induced by leukaemia-inhibitory factor may be due to toxicity(7). In the murine adenocarcinoma MAC16, cachexia is mediated by circulatory catabolic factors(8,9), which we have now isolated using an antibody cloned from splenocytes of mice transplanted with the MAC16 tumour, with a delayed cachexia(10). The material is a proteoglycan of relative molecular mass 24K which produces cachexia in vivo by inducing catabolism of skeletal muscle. The 24K material was also present in urine of cachectic cancer patients, but was absent from normal subjects, patients with weight loss due to trauma, and cancer patients with little or no weight loss. This suggests that cachexia in mice and humans may be produced by the same material. |
| Document Type: Article |
| Language: English |
Addresses:
1. UNIV ASTON, INST PHARMACEUT SCI, CRC, NUTR BIOCHEM RES GRP, BIRMINGHAM B4 7ET, W MIDLANDS ENGLAND
2. UNIV COLL & MIDDLESEX SCH MED, DEPT BIOCHEM, CRC, MOLEC TOXICOL GRP, LONDON W1P 6D8, ENGLAND
3. UNIV EDINBURGH, ROYAL INFIRM, DEPT SURG, EDINBURGH EH3 9YW, MIDLOTHIAN SCOTLAND |
| Publisher: MACMILLAN MAGAZINES LTD, 4 LITTLE ESSEX STREET, LONDON, ENGLAND WC2R 3LF |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: TW567 |
| ISSN: 0028-0836 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |