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| The FHIT gene, spanning the chromosome 3p14.2 fragile site acid renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers |
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| Author(s): Ohta M, Inoue H, Cotticelli MG, Kastury K, Baffa R, Palazzo J, Siprashvili Z, Mori M, McCue P, Druck T, Croce CM, Huebner K |
| Source: CELL Volume: 84 Issue: 4 Pages: 587-597 Published: FEB 23 1996 |
| Times Cited: 765 References: 37 |
| Abstract: A 200-300 kb region of chromosome 3p14.2, including the fragile site locus FRA3B, is homozygously deleted in multiple tumor-derived cell lines. Exon amplification from cosmids covering this deleted region allowed identification of the human FHIT gene, a member of the histidine triad gene family, which encodes a protein with 69% similarity to an S. pombe enzyme, diadenosine 5', 5triple prime P-1, P-4-tetraphosphate asymmetrical hydrolase. The FHIT locus is composed of ten exons distributed over at least 500 kb, with three 5' untranslated exons centromeric to the renal carcinoma-associated 3p14.2 breakpoint, the remaining exons telomeric to this translocation breakpoint, and exon 5 within the homozygously deleted fragile region. aberrant transcripts of the FHIT locus were found in similar to 50% of esophageal, stomach, and colon carcinomas. |
| Document Type: Article |
| Language: English |
Addresses:
1. THOMAS JEFFERSON UNIV, JEFFERSON MED COLL, KIMMEL CANC CTR, PHILADELPHIA, PA 19107 USA
2. KYUSHU UNIV, MED INST BIOREGULAT, DEPT SURG, BEPPU, OITA 874 JAPAN |
| Publisher: CELL PRESS, 1050 MASSACHUSETTES AVE, CIRCULATION DEPT, CAMBRIDGE, MA 02138 |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology |
| IDS Number: TX176 |
| ISSN: 0092-8674 |
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