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| Mapping of a susceptibility locus for Crohn's disease on chromosome 16 |
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| Author(s): Hugot JP, LaurentPuig P, GowerRousseau C, Olson JM, Lee JC, Beaugerie L, Naom I, Dupas JL, VanGossum A, Orholm M, BonaitiPellie C, Weissenbach J, Mathew CG, LennardJones JE, Cortot A, Colombel JF, Thomas G |
| Source: NATURE Volume: 379 Issue: 6568 Pages: 821-823 Published: FEB 29 1996 |
| Times Cited: 601 References: 27 |
| Abstract: Crohn's disease (CD) and ulcerative colitis are the major forms of chronic inflammatory bowel diseases in the western world, and occur in young adults with an estimated prevalence of more than one per thousand inhabitants'. The causes of inflammatory bowel diseases remain unknown, but genetic epidemiology studies(2-5) suggest that inherited factors may contribute in part to variation in individual susceptibility to Crohn's disease. A genome-wide search performed on two consecutive and independent panels of families with multiple affected members, using a non-parametric two-point sibling-pair linkage method, identified a putative CD-susceptibility locus on chromosome 16 (P < 0.01 for each panel). The localization was centred around loci D16S409 and D16S419 by using multipoint sibpair analysis (ref. 6, and J.M.O., manuscript submitted) (P < 1.5 x 10(-5)). This region of the genome contains candidate genes which may be relevant to the pathogenic mechanism of inflammatory bowel diseases. |
| Document Type: Article |
| Language: English |
Addresses:
1. INST CURIE, LAB GENET TUMEURS, INSERM, U434, F-75231 PARIS, FRANCE
2. CTR HOSP REG & UNIV LILLE, REGISTRE MALAD INFLAMMATOIRES TUBE DIGEST NORD QU, F-59037 LILLE, FRANCE
3. CASE WESTERN RESERVE UNIV, DEPT EPIDEMIOL & BIOSTAT, CLEVELAND, OH 44109 USA
4. ST MARKS HOSP, LONDON EC1V 2PS, ENGLAND
5. HOP ROTHSCHILD, SERV GASTROENTEROL & HEPTAOL, F-75571 PARIS, FRANCE
6. UNITED MED & DENT SCH, GUYS & ST THOMAS HOSP, DIV MED & MOLEC GENET, LONDON SE1 9RT, ENGLAND
7. HOP NORD AMIENS, SERV HEPATOGASTROENTEROL, F-80054 AMIENS, FRANCE
8. HOP ERASME, SERV GASTROENTEROL & HEPATOPANCREATOL, B-1070 BRUSSELS, BELGIUM
9. GRP ETUD THERAPEUT AFFECT INFLAMMATORIES DIGEST, F-75012 PARIS, FRANCE
10. HERLEV HOSP, DEPT MED GASTROENTEROL, COPENHAGEN, DENMARK
11. INST GUSTAVE ROUSSY, CANC EPIDEMIOL UNIT, F-94805 VILLEJUIF, FRANCE
12. GENETHON, CNRS, URA 1922, F-91002 EVRY, FRANCE |
| Publisher: MACMILLAN MAGAZINES LTD, 4 LITTLE ESSEX STREET, LONDON, ENGLAND WC2R 3LF |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: TX501 |
| ISSN: 0028-0836 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |