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| BRCA1 is secreted and exhibits properties of a granin |
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| Author(s): Jensen RA, Thompson ME, Jetton TL, Szabo CI, vanderMeer R, Helou B, Tronick SR, Page DL, King MC, Holt JT |
| Source: NATURE GENETICS Volume: 12 Issue: 3 Pages: 303-308 Published: MAR 1996 |
| Times Cited: 184 References: 20 |
| Abstract: Germline mutations in BRCA1 are responsible for most cases of inherited breast and ovarian cancer. However, the function of the BRCA1 protein has remained elusive. We now show that BRCA1 encodes a 190-kD protein with sequence homology and biochemical analogy to the granin protein family. Interestingly, BRCA2 also includes a motif similar to the granin consensus at the C terminus of the protein. Both BRCA1 and the granins localize to secretory vesicles, are secreted by a regulated pathway, are posttranslationally glycosylated and are responsive to hormones. As a regulated secretory protein, BRCA1 appears to function by a mechanism not previously described for tumour suppressor gene products. |
| Document Type: Article |
| Language: English |
| Reprint Address: Jensen, RA (reprint author), VANDERBILT UNIV, SCH MED, DEPT PATHOL, 221 KIRKLAND HALL, NASHVILLE, TN 37232 USA |
Addresses:
1. VANDERBILT UNIV, SCH MED, DEPT CELL BIOL, NASHVILLE, TN 37232 USA
2. VANDERBILT UNIV, SCH MED, DEPT MOLEC PHYSIOL & BIOPHYS, NASHVILLE, TN 37232 USA
3. VANDERBILT UNIV, SCH MED, DEPT PREVENT MED, NASHVILLE, TN 37232 USA
4. UNIV WASHINGTON, DEPT MED, SEATTLE, WA 98195 USA
5. UNIV WASHINGTON, DEPT GENET, SEATTLE, WA 98195 USA
6. SANTA CRUZ BIOTECHNOL, SANTA CRUZ, CA 95060 USA |
| Publisher: NATURE PUBLISHING CO, 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 |
| Subject Category: Genetics & Heredity |
| IDS Number: TY183 |
| ISSN: 1061-4036 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |